Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice

<table>Human nasopharyngeal carcinoma FaDu cells were exposed to chemicals for 48 h and toxicity was determined by the MTS assay. The rank orders of LC50 are sodium arsenite (35 μM) &gt; arsenic trioxide (280 μM), arsenate (400 μM) &gt;NHJD (1200 μM) &gt; realgar (As2S2, 2000 μM; As4S4, 3000 μM). Data are mean ± SE of 5 separate experiments.</table>

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Figure 1: Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice