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Research Article

Water-soluble Fraction of Abelmoschus esculentus L Interacts with Glucose and Metformin Hydrochloride and Alters Their Absorption Kinetics after Coadministration in Rats

Table 1

Blood glucose level (mmol/L) after oral administration of glucose, WSF of okra, and CMC.
Treatment groups0 hr2 hrs4 hrs8 hrs12 hrs24 hrs
NC 7 . 0 ± 0 . 0 2 6 . 7 ± 0 . 1 2 7 . 0 ± 0 . 1 9 6 . 8 ± 0 . 0 4 6 . 9 ± 0 . 0 5 6 . 8 ± 0 . 1 3
FC 4 . 0 ± 0 . 0 3 3 . 9 ± 1 . 0 5 3 . 8 ± 0 . 0 5 3 . 6 ± 0 . 0 5 3 . 5 ± 0 . 0 6 3 . 1 ± 0 . 0 5
FG 4 . 1 ± 0 . 1 0 7 . 2 ± 0 . 1 0 6 . 8 ± 0 . 0 2 5 . 6 . ± 1 . 0 2 4 . 3 . ± 1 . 0 0 3 . 2 ± 0 . 0 3
FGF 3 . 9 ± 0 . 1 2 4 . 7 ± 0 . 2 3 a , b 3 . 8 ± 1 . 2 4 a , b 3 . 5 ± 0 . 2 4 3 . 2 ± 0 . 4 0 3 . 1 ± 0 . 1 9
FGC 3 . 8 ± 1 . 0 4 6 . 8 ± 0 . 9 5 5 . 9 ± 1 . 3 5 4 . 7 ± 2 . 0 4 3 . 8 ± 0 . 9 0 3 . 2 ± 1 . 0 7
Values are expressed as mean ± SEM of 6 rats/group. NC: normal control; FC: fasting control; FG: fasting with glucose (2 gm/kg b.w.); FGF: fasting with glucose (2 gm/kg b.w.) and WSF of A. esculentus (2 gm/kg b.w.); and FGC: fasting with glucose and CMC. a 𝑃 < 0 . 0 5 compared to FG; b 𝑃 < 0 . 0 5 compared to FGC (ANOVA followed by Dunnett's test).