Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011 (2011), Article ID 264978, 11 pages
http://dx.doi.org/10.5402/2011/264978
Research Article

Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

1Division of Radiation Oncology, Department of Radiology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23314, USA
2Department of Clinical Studies (Hiroshima), Radiation Effects Research Foundation (RERF), 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
3Department of Statistics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
4Department of Genetics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
5Associate Chief of Research, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
6Department of Radiation Biology/Molecular Epidemiology, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
7Department of Clinical Studies (Nagasaki), RERF, 8-6 Nakagawa 1-chome, Nagasaki City, Japan

Received 17 August 2010; Accepted 21 September 2010

Academic Editors: A. Gompel and Z. M. Lei

Copyright © 2011 Edward F. Miles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. There is evidence in the literature of increased maternal radiosensitivity during pregnancy. Materials and Methods. We tested this hypothesis using information from the atomic-bomb survivor cohort, that is, the Adult Health Study database at the Radiation Effects Research Foundation, which contains data from a cohort of women who were pregnant at the time of the bombings of Hiroshima and Nagasaki. Previous evaluation has demonstrated long-term radiation dose-response effects. Results/Conclusions. Data on approximately 250 women were available to assess dose-response rates for serum cholesterol, white blood cell count, erythrocyte sedimentation rate, and serum hemoglobin, and on approximately 85 women for stable chromosome aberrations, glycophorin A locus mutations, and naïve CD4 T-cell counts. Although there is no statistically significant evidence of increased radiosensitivity in pregnant women, the increased slope of the linear trend line in the third trimester with respect to stable chromosome aberrations is suggestive of an increased radiosensitivity.