Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011, Article ID 264978, 11 pages
http://dx.doi.org/10.5402/2011/264978
Research Article

Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

1Division of Radiation Oncology, Department of Radiology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23314, USA
2Department of Clinical Studies (Hiroshima), Radiation Effects Research Foundation (RERF), 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
3Department of Statistics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
4Department of Genetics, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
5Associate Chief of Research, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
6Department of Radiation Biology/Molecular Epidemiology, RERF, 5-2 Hijiyama Park, Minami-ku, Hiroshima City, Japan
7Department of Clinical Studies (Nagasaki), RERF, 8-6 Nakagawa 1-chome, Nagasaki City, Japan

Received 17 August 2010; Accepted 21 September 2010

Academic Editors: A. Gompel and Z. M. Lei

Copyright © 2011 Edward F. Miles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Baeyens, V. Vandersickel, H. Thierens, L. De Ridder, and A. Vral, “Effects of estradiol and progesterone on the variability of the micronucleus assay,” Mutation Research, vol. 578, no. 1-2, pp. 308–316, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. M. J. Evans, S. MacLaughlin, R. D. Marvin, and N. I. Abdou, “Estrogen decreases in vitro apoptosis of peripheral blood mononuclear cells from women with normal menstrual cycles and decreases TNF-α production in SLE but not in normal cultures,” Clinical Immunology and Immunopathology, vol. 82, no. 3, pp. 258–262, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Kanda and I. Hayata, “Effect of estradiol on radiation-induced chromosome aberrations in human lymphocytes,” Journal of Radiation Research, vol. 40, no. 2, pp. 95–100, 1999. View at Google Scholar · View at Scopus
  4. J. E. N. Morten, D. G. Harnden, and A. M. R. Taylor, “Chromosome damage in G0 X-irradiated lymphocytes from patients with hereditary retinoblastoma,” Cancer Research, vol. 41, no. 9, pp. 3635–3638, 1981. View at Google Scholar · View at Scopus
  5. M. Ricoul and B. Dutrillaux, “Variations of chromosome radiation sensitivity in fetal and adult mice during gestation,” Mutation Research, vol. 250, no. 1-2, pp. 331–335, 1991. View at Google Scholar · View at Scopus
  6. M. Ricoul and B. Dutrillaux, “Pregnancy increases gamma ray sensitivity of chromosomes in the mouse,” Comptes Rendus de l'Academie des Sciences - Serie III, vol. 312, no. 13, pp. 635–639, 1991. View at Google Scholar · View at Scopus
  7. M. Ricoul, J. Lebeau, L. Sabatier, and B. Dutrillaux, “Increased radiation-induced chromosome breakage after progesterone addition at the G1/S-phase transition,” Mutation Research, vol. 403, no. 1-2, pp. 177–183, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Ricoul, L. Sabatier, and B. Dutrillaux, “Increased chromosome radiosensitivity during pregnancy,” Mutation Research, vol. 374, no. 1, pp. 73–78, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. C. J. Roberts, G. R. Morgan, and N. Danford, “Effect of hormones on the variation of radiosensitivity in females as measured by induction of chromosomal aberrations,” Environmental Health Perspectives, vol. 105, no. 6, pp. 1467–1471, 1997. View at Google Scholar · View at Scopus
  10. T. Sharma and B. C. Das, “Higher incidence of spontaneous sister-chromatid exchanges (SCEs) and X-ray-induced chromosome aberrations in peripheral blood lymphocytes during pregnancy,” Mutation Research, vol. 174, no. 1, pp. 27–33, 1986. View at Google Scholar · View at Scopus
  11. G. Vares, K. Ory, B. Lectard et al., “Progesterone prevents radiation-induced apoptosis in breast cancer cells,” Oncogene, vol. 23, no. 26, pp. 4603–4613, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Kodama, D. Pawel, N. Nakamura et al., “Stable chromosome aberrations in atomic bomb survivors: Results from 25 years of investigation,” Radiation Research, vol. 156, no. 4, pp. 337–346, 2001. View at Google Scholar · View at Scopus
  13. Y. Kusunoki, M. Yamaoka, F. Kasagi et al., “T cells of atomic bomb survivors respond poorly to stimulation by Staphylococcus aureus toxins in vitro: does this stem from their peripheral lymphocyte populations having a diminished naïve CD4 T-cell content?” Radiation Research, vol. 158, no. 6, pp. 715–724, 2002. View at Google Scholar · View at Scopus
  14. S. Kyoizumi, M. Akiyama, J. B. Cologne et al., “Somatic cell mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors: implications for radiation carcinogenesis,” Radiation Research, vol. 146, no. 1, pp. 43–52, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Neriishi, E. Nakashima, and R. R. Delongchamps, “Persistent subclinical inflammation among A-bomb survivors,” International Journal of Radiation Biology, vol. 77, no. 4, pp. 475–482, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. F. L. Wong, M. Yamada, H. Sasaki, K. Kodama, and Y. Hosoda, “Effects of radiation on the longitudinal trends of total serum cholesterol levels in the atomic bomb survivors,” Radiation Research, vol. 151, no. 6, pp. 736–746, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. F. L. Wong, M. Yamada, T. Tominaga, S. Fujiwara, and G. Suzuki, “Effects of radiation on the longitudinal trends of hemoglobin levels in the Japanese atomic bomb survivors,” Radiation Research, vol. 164, no. 6, pp. 820–827, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Kyoizumi, Y. Kusunoki, T. Hayashi, M. Hakoda, J. B. Cologne, and K. Nakachi, “Individual variation of somatic gene mutability in relation to cancer susceptibility: prospective study on erythrocyte glycophorin A gene mutations of atomic bomb survivors,” Cancer Research, vol. 65, no. 12, pp. 5462–5469, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. H. C. Sox Jr. and M. H. Liang, “The erythrocyte sedimentation rate. Guidelines for rational use,” Annals of Internal Medicine, vol. 104, no. 4, pp. 515–523, 1986. View at Google Scholar · View at Scopus
  20. A. A. Awa, M. Nakano, K. Ohtaki, Y. Kodama, J. Lucas, and J. Gray, “Factors that determine the in vivo dose-response relationship for stable chromosome aberrations in A-bomb survivors,” Journal of Radiation Research, vol. 33, pp. 206–214, 1992. View at Google Scholar · View at Scopus
  21. U. Hoeller, K. Borgmann, M. Bonacker et al., “Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer,” Radiotherapy and Oncology, vol. 69, no. 2, pp. 137–144, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. L. A. Jones, D. Scott, R. Cowan, and S. A. Roberts, “Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation,” International Journal of Radiation Biology, vol. 67, no. 5, pp. 519–528, 1995. View at Google Scholar · View at Scopus
  23. S. Neubauer, J. Dunst, and E. Gebhart, “The impact of complex chromosomal rearrangements on the detection of radiosensitivity in cancer patients,” Radiotherapy and Oncology, vol. 43, no. 2, pp. 189–195, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Catena, D. Conti, P. Parasacchi et al., “Micronuclei in cytokinesis-blocked lymphocytes may predict patient response to radiotherapy,” International Journal of Radiation Biology, vol. 70, no. 3, pp. 301–308, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. D. N. Floyd and A. M. Cassoni, “Intrinsic radiosensitivity of adult and cord blood lymphocytes as determined by the micronucleus assay,” European Journal of Cancer Part A, vol. 30, no. 5, pp. 615–620, 1994. View at Publisher · View at Google Scholar · View at Scopus
  26. C. R. Geard and C. Y. Chen, “Micronuclei and clonogenicity following low- and high-dose-rate γ irradiation of normal human fibroblasts,” Radiation Research, vol. 124, no. 1, pp. S56–S61, 1990. View at Publisher · View at Google Scholar · View at Scopus
  27. T.-K. Lee, R. R. Allison, K. F. O'Brien et al., “Lymphocyte radiosensitivity correlated with pelvic radiotherapy morbidity,” International Journal of Radiation Oncology Biology Physics, vol. 57, no. 1, pp. 222–229, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. J. P. Svensson, L. J. Stalpers, R. E. Esveldt-van Lange et al., “Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity,” PLoS Medicine, vol. 3, no. 10, article e422, 2006. View at Google Scholar · View at Scopus
  29. R. Sposto, D. O. Stram, and A. A. Awa, “An estimate of the magnitude of random errors in the DS86 dosimetry from data on chromosome aberrations and severe epilation,” Radiation Research, vol. 128, no. 2, pp. 157–169, 1991. View at Google Scholar · View at Scopus
  30. Y. Kusunoki, S. Kyoizumi, Y. Hirai et al., “Flow cytometry measurements of subsets of t, b and nk cells in peripheral blood lymphocytes of atomic bomb survivors,” Radiation Research, vol. 150, no. 2, pp. 227–236, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. C. H. McCollough, B. A. Schueler, T. D. Atwell et al., “Radiation exposure and pregnancy: when should we be concerned?” Radiographics, vol. 27, no. 4, pp. 909–917, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. C. K. Osborne, D. H. Boldt, G. M. Clark, and J. M. Trent, “Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase,” Cancer Research, vol. 43, no. 8, pp. 3583–3585, 1983. View at Google Scholar · View at Scopus
  33. D. E. Wazer, O. F. Tercilla, P.-S. Lin, and R. Schmidt-Ullrich, “Modulation in the radiosensitivity of MCF-7 human breast carcinoma cells by 17B-estradiol and tamoxifen,” British Journal of Radiology, vol. 62, no. 744, pp. 1079–1083, 1989. View at Google Scholar · View at Scopus
  34. P. H. Ahn, H. T. Vu, D. Lannin et al., “Sequence of radiotherapy with tamoxifen in conservatively managed breast cancer does not affect local relapse rates,” Journal of Clinical Oncology, vol. 23, no. 1, pp. 17–23, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. E. E. R. Harris, V. J. Christensen, W.-T. Hwang, K. Fox, and L. J. Solin, “Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatment,” Journal of Clinical Oncology, vol. 23, no. 1, pp. 11–16, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. L. J. Pierce, L. F. Hutchins, S. R. Green et al., “Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancer,” Journal of Clinical Oncology, vol. 23, no. 1, pp. 24–29, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. W. Dörr, S. Bertmann, and T. Herrmann, “Radiation induced lung reactions in breast cancer therapy: modulating factors and consequential effects,” Strahlentherapie und Onkologie, vol. 181, no. 9, pp. 567–573, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Azria, S. Gourgou, W. J. Sozzi et al., “Concomitant use of tamoxifen with radiotherapy enhances subcutaneous breast fibrosis in hypersensitive patients,” British Journal of Cancer, vol. 91, no. 7, pp. 1251–1260, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Azria, C. Larbouret, S. Cunat et al., “Letrozole sensitizes breast cancer cells to ionizing radiation,” Breast Cancer Research, vol. 7, no. 1, pp. R156–R163, 2005. View at Google Scholar · View at Scopus
  40. O. Ademuyiwa, O. L. Odusoga, O. O. Adebawo, and R. N. Ugbaja, “Endogenous antioxidant defences in plasma and erythrocytes of pregnant women during different trimesters of pregnancy,” Acta Obstetricia et Gynecologica Scandinavica, vol. 86, no. 10, pp. 1175–1180, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. M. T. M. Raijmakers, E. M. Roes, L. Poston, E. A. P. Steegers, and W. H. M. Peters, “The transient increase of oxidative stress during normal pregnancy is higher and persists after delivery in women with pre-eclampsia,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 138, no. 1, pp. 39–44, 2008. View at Publisher · View at Google Scholar · View at Scopus