Biomarkers of Radiosensitivity in A-Bomb Survivors Pregnant at the Time of Bombings in Hiroshima and Nagasaki

Table 3

Summary of expected and actual findings in pregnant A-bomb survivors—direct effects.

(a)

Parameter; (Reference interval)	Expected change with pregnancy	Regression Coefficients		Standard Error	𝑃-value
Log-Cholesterol (143–220 mg/dl)∗		(Log-mg/dl/Gy)
Overall		+0.006		0.005	.259
Pregnant		−0.015		0.020	.435
Not pregnant		+0.007		0.005	.166
Difference					.264
Log-WBC count (33–9110^3cells/cm3)∗∗		(Log-cells/cm3/Gy)
Overall		−0.001		0.004	.726
Pregnant		−0.009		0.019	.633
Not pregnant		+0.002		0.004	.646
Difference					.573
ESR (0–40 mm/hr)∗∗		(mm/hr/Gy)
Overall		+0.485		0.427	.255
Pregnant		−2.884		2.189	.188
Not pregnant		+0.617		0.435	.156
Difference					.117
HGB (11–15 g/dl)∗∗		(g/dl/Gy)
Overall		−0.067		0.039	.088
Pregnant		+0.139		0.187	.456
Not pregnant		−0.077		0.040	.057
Difference					.258

∗Adjusted for age and city.
∗∗Adjusted for age, city, smoking, inflammatory disease, and any cancer.

(b)

Parameter	Expected change with pregnancy	Regression Coefficients		Standard Error	𝑃-value
Chromosome aberration∗∗		(freq/cell/Gy)
Overall		+0.0708		0.00439	<.001
Pregnant		+0.0864		0.0194	<.001
Not pregnant		+0.0699		0.00450	<.001
Difference					.403
Log-GPA locus mutation∗		(Log-mut/Gy)
Overall		+0.281		0.029	<.001
Pregnant		+0.414		0.141	.004
Not pregnant		+0.275		0.029	<.001
Difference					.337
Naïve CD-4 T-cell count∗		(cells/Gy)
Overall		−1.425		0.419	.001
Pregnant		−1.551		1.939	.424
Not pregnant		−1.419		0.429	.001
Difference					.947

∗Adjusted for age and city.
∗∗Adjusted for age, city, and smoking.