Table of Contents
ISRN Neurology
Volume 2011 (2011), Article ID 265253, 10 pages
http://dx.doi.org/10.5402/2011/265253
Research Article

Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome: Insights of Using Fused Domains in Hypothetical Proteins as Probes

1Department of Bioinformatics, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu 603 203, India
2Physics Department, Bangalore University, Jnanabharathi Campus, Bangalore 560 056, India
3Department of Biotechnology, Sir M. Visvesvaraya Institute of Technology, Near Hunasamaranahalli, Via Yelahanka, Bangalore 562 157, India

Received 20 April 2011; Accepted 21 May 2011

Academic Editors: A. Conti, C. Johansson, A. Mamelak, and B. Moreno-López

Copyright © 2011 N. Rathankar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

High-throughput genome sequencing has led to data explosion in sequence databanks, with an imbalance of sequence-structure-function relationships, resulting in a substantial fraction of proteins known as hypothetical proteins. Functions of such proteins can be assigned based on the analysis and characterization of the domains that they are made up of. Domains are basic evolutionary units of proteins and most proteins contain multiple domains. A subset of multidomain proteins is fused domains (overlapping domains), wherein sequence overlaps between two or more domains occur. These fused domains are a result of gene fusion events and their implication in diseases is well established. Hence, an attempt has been made in this paper to identify the fused domain containing hypothetical proteins from human genome homologous to parkinsonian targets present in KEGG database. The results of this research identified 18 hypothetical proteins, with domains fused with ubiquitin domains and having homology with targets present in parkinsonian pathway.