Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome: Insights of Using Fused Domains in Hypothetical Proteins as Probes

Table 2

A description of genes, domains, and type of inheritance for Parkinson’s disease (source: Nirit Lev and Melamed [1]).

Gene/locus/assignment	Domains present	Inheritance	Age of onset
a-Synuclein/SNCA/PARK1 & 4	Synuclein/ubiquitin-like	Autosomal dominant/susceptibility	Early/late
Parkin/PRKN/PARK2	Parkin and ubiquitin	Autosomal recessive/possible susceptibility	Juvenile/early
Ubiquitin C-terminal hydrolase/UCH-L1/PARK5	Peptidase, ubiquitin	Autosomal dominant/susceptibility	Late
DJ-1/DJ-1/PARK7	GATase/ubiquitin-like	Autosomal recessive	Early