Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin

Table 2

Formulation of amoxicillin in situ gel using different concentrations of sodium bicarbonate.

Name of ingredient	Quantity in 100 mL (% w/v)
	𝐶-1	𝐶-2	𝐶-3
Amoxicillin	7.5	7.5	7.5
Calcium chloride	0.15	0.15	0.15
Sodium citrate	0.5	0.5	0.5
Sodium alginate	2.5	2.5	2.5
HPMC K100	0.8	0.8	0.8
Sodium bicarbonate	1	1.5	2
Deionised water	Q.S	Q.S	Q.S
Floating lag time (s)	55	48	30
CPR at 6 h (%)	67.50	71.57	82.84

CPR indicates cumulative percentage release; HPMC K100 indicates hydroxypropyl methyl cellulose K100; Q.S indicates quantity sufficient.