Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia: First-in-Human, Proof-of-Concept Trial

Table 3

Adverse events of patients after each vaccination.

1st vaccination

2nd vaccination

3rd vaccination

4th vaccination

Patients

p

a

r

s

sys

p

a

r

s

sys

p

a

r

s

sys

p

a

r

s

sys

01

x

x

x

x

02

x

x

x

x

x

x

x

x

x

03

x

x

x

x

x

1,2,3

04

x

x

x

x

4

x

x

05

x

x

x

06

x

x

x

x

x

x

x

x

07

x

x

2

x

x

x

x

x

x

Abbreviations
p, pain at vaccination site.
a, ardor at vaccination site.
r, redness at vaccination site.
s, swelling at vaccination site.
sys, systemic responses. 1-fever; 2-tremors; 3-Lower abdomen pain; 4-cramps.