Table of Contents
ISRN Pharmacology
Volume 2011, Article ID 314209, 11 pages
Research Article

Novel Phenazine 5,10-Dioxides Release OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo

1Grupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de la República, 11400 Montevideo, Uruguay
2Cátedra de Análisis Clínicos, Laboratorio Central—Hospital Maciel (Ministerio de Salud Pública), Facultad de Química, Universidad de la República, 11200 Montevideo, Uruguay
3Departamento de Patobiología, Facultad de Veterinaria, Universidad de la República, 11600 Montevideo, Uruguay
4Department of Biochemistry and Molecular Biology, Faculty of Biology, Institute of Biomedicine of University of Barcelona (IBUB) and IDIBAPS, Unit Associated with CSIC, 08028 Barcelona, Spain
5Departamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 83800005 Santiago, Chile
6Centro de Investigaciones en Farmacobiología Aplicada, Universidad de Navarra, 31008 Pamplona, Spain

Received 16 February 2011; Accepted 14 April 2011

Academic Editor: P. Cos

Copyright © 2011 María L. Lavaggi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Appendix (5 pages) with supplementary data about treatment schedules (Figure 1S), determination of MTD (Table 1S), biochemical and haematological findings (Table 2S), and summary of histopathologic findings (Table 3S) is located at doi: 10.5402/2011/314209

  1. Supplementary Material