Table of Contents
ISRN Cardiology
Volume 2011 (2011), Article ID 319453, 2 pages
http://dx.doi.org/10.5402/2011/319453
Case Report

Sterile Abscess in the Myocardium after Direct Intramyocardial Injection Related to Gene Therapy in a Swine Model

Cardiovascular Research Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1030, New York, NY 10029-6574, USA

Received 15 February 2011; Accepted 15 March 2011

Academic Editors: C. Briguori, C. Gonzalez-Juanatey, and K. D. Schluter

Copyright © 2011 Kiyotake Ishikawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiac gene therapy is one of the most promising approaches to cure patients with cardiac dysfunctions. Many ways of efficient gene transfer using viral vectors are tested, and some of them are already used in clinical settings. However, it is always important to be keenly alert to the possible complications when a new therapy is introduced. We present a case of myocardial sterile abscess in a swine model associated with a direct myocardial injection.