Mgat5 Deficiency in T Cells and Experimental Autoimmune Encephalomyelitis

Figure 1

GlcNAc-branched N-glycan biosynthesis. UDP-GlcNAc is required by the N-acetylglucosaminyltransferases Mgat1, 2, 4, and 5 and iGnT. Cytosolic UDP-GlcNAc enters the Golgi via antiporter exchange with Golgi UMP, a reaction product of the N-acetylglucosaminyltransferases. Galectins bind N-acetyllactosamine, with avidity increasing in proportion to the number of N-acetyllactosamine units (i.e., branching). β-1,6-GlcNAc-branching by 𝑀𝑔𝑎𝑡5 promotes poly-N-acetyllactosamine production, further enhancing avidity for galectins. GalT3, galactosyltransferase 3.