Table of Contents
ISRN Oncology
Volume 2011, Article ID 390676, 5 pages
http://dx.doi.org/10.5402/2011/390676
Review Article

Anti-Inflammatory Drugs Reduce the Risk of Hepatocellular Carcinoma Development

1Department of Surgery, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
2Tarao Clinic, 2-58-6 Futamatagawa, Asahi-ku, Yokohama 241-0821, Japan

Received 4 April 2011; Accepted 18 May 2011

Academic Editor: N. T. Telang

Copyright © 2011 Yasushi Rino and Kazuo Tarao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Slaga and J. D. Scribner, “Inhibition of tumor initiation and promotion by antiinflammatory agents,” Journal of the National Cancer Institute, vol. 51, no. 5, pp. 1723–1725, 1973. View at Google Scholar · View at Scopus
  2. R. Cameron, G. Lee, and E. Farber, “Chemical mitogens as effective alternatives to partial hepatectomy in the new model for the sequential analysis of hepatocarcinogenesis,” Proceedings of the American Association for Cancer Research, vol. 19, 222 pages, 1978. View at Google Scholar
  3. F. Marks, S. Bertsch, W. Grimm et al., “Hyperplastic transformation and tumor promotion in mouse epidermis: possible consequences of disturbances of endogenous mechanism controlling proliferation and differentiation,” in Carcinogenesis, T. J. Slaga, A. Sivak, and R. K. Boutwell, Eds., vol. 2, pp. 97–116, Raven Press, New York, NY, USA, 1978. View at Google Scholar
  4. T. S. Argyris, “Tumor promotion by damage-induced epidermal hyperplasia in the skin of mice,” Proceedings of the American Association for Cancer Research, vol. 20, no. 4, 1979. View at Google Scholar
  5. M. Asaka, M. Kato, and D. Y. Graham, “Prevention of gastric cancer by Helicobacter pylori eradication,” Internal Medicine, vol. 49, no. 7, pp. 633–636, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. E. Lennard-Jones, D. M. Melville, B. C. Morson, J. K. Ritchie, and C. B. Williams, “Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years,” Gut, vol. 31, no. 7, pp. 800–806, 1990. View at Google Scholar · View at Scopus
  7. J. Belamaric, “Intrahepatic bile duct carcinoma and C. sinensis infection in Hong Kong,” Cancer, vol. 31, no. 2, pp. 468–473, 1973. View at Google Scholar · View at Scopus
  8. S. Sugihara and M. Kojiro, “Pathology of cholangiocarcinoma,” in Neoplasms of the Liver, K. Okuda and K. G. Ishak, Eds., pp. 143–158, Springer, Tokyo, Japan, 1987. View at Google Scholar
  9. K. Ikeda, S. Saitoh, Y. Arase et al., “Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: a long-term observation study of 1,643 patients using statistical bias correction with proportional hazard analysis,” Hepatology, vol. 29, no. 4, pp. 1124–1130, 1999. View at Google Scholar · View at Scopus
  10. Y. Shiratori, F. Imazeki, M. Moriyama et al., “Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy,” Annals of Internal Medicine, vol. 132, no. 7, pp. 517–524, 2000. View at Google Scholar · View at Scopus
  11. K. Okita, I. Sakaida, and K. Hino, “Current strategies for chemoprevention of hepatocellular carcinoma,” Oncology, vol. 62, no. 1, pp. 24–28, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Tarao, S. Takemiya, S. Tamai et al., “Relationship between the recurrence of hepatocellular carcinoma (HCC) and serum alanine aminotransferase levels in hepatectomized patients with hepatitis C virus-associated cirrhosis and HCC,” Cancer, vol. 79, no. 4, pp. 688–694, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Tarao, Y. Rino, S. Ohkawa et al., “Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis,” Cancer, vol. 86, no. 4, pp. 589–595, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Tarao, Y. Rino, S. Takemiya et al., “Close association between high serum ALT and more rapid recurrence of hepatocellular carcinoma in hepatectomized patients with HCV-associated liver cirrhosis and hepatocellular carcinoma,” Intervirology, vol. 43, no. 1, pp. 20–26, 2000. View at Google Scholar · View at Scopus
  15. K. Tarao, Y. Rino, S. Ohkawa et al., “Close association between high serum alanine aminotransferase levels and multicentric hepatocarcinogenesis in patients with hepatitis C virus-associated cirrhosis,” Cancer, vol. 94, no. 6, pp. 1787–1795, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. K. Tarao, Y. Rino, S. Takemiya et al., “Serum alanine aminotransferase levels and survival after hepatectomy in patients with hepatocellular carcinoma and hepatitis C virus-associated liver cirrhosis,” Cancer Science, vol. 94, no. 12, pp. 1083–1090, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Rino, K. Tarao, S. Morinaga et al., “Reduction therapy of alanine aminotransferase levels prevent HCC development in patients with HCV-associated cirrhosis,” Anticancer Research, vol. 26, no. 3, pp. 2221–2226, 2006. View at Google Scholar · View at Scopus
  18. H. Yano, A. Mizoguchi, K. Fukuda et al., “The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase,” Cancer Research, vol. 54, no. 2, pp. 448–454, 1994. View at Google Scholar · View at Scopus
  19. H. Suzuki, Y. Ohta, and T. Takino, “Effects of glycyrrhizin on biochemical tests in patients with chronic hepatitis. Double blind trial,” Asian Medical Journal, vol. 26, no. 7, pp. 423–438, 1983. View at Google Scholar · View at Scopus
  20. C. Hirayama, M. Okumura, K. Tanikawa, M. Yano, M. Mizuta, and N. Ogawa, “A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis,” Gastroenterologia Japonica, vol. 24, no. 6, pp. 715–719, 1989. View at Google Scholar · View at Scopus
  21. S. Bellentani, M. Podda, C. Tiribelli et al., “Ursodiol in the long-term treatment of chronic hepatitis: a double-blind multicenter clinical trial,” Journal of Hepatology, vol. 19, no. 3, pp. 459–464, 1993. View at Google Scholar · View at Scopus
  22. K. Miyakawa, K. Tarao, K. Ohshige et al., “High serum alanine aminotransferase levels for the first three successive years can predict very high incidence of hepatocellular carcinoma in patients with Child Stage A HCV-associated liver cirrhosis,” Scandinavian Journal of Gastroenterology, vol. 44, no. 11, pp. 1340–1348, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. S. Ferenc, M. Bela, Z. Tamas, B. Lajos, and T. Zsolt, “Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: ulcerative colitis shows specific p53- and EGFR expression alterations,” Diseases of the Colon and Rectum, vol. 48, no. 4, pp. 775–786, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. H. Kasai and S. Nishimura, “Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents,” Nucleic Acids Research, vol. 12, no. 4, pp. 2137–2145, 1984. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Shibutani, M. Takeshita, and A. P. Grollman, “Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG,” Nature, vol. 349, no. 6308, pp. 431–434, 1991. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. G. Shiota, Y. Maeta, T. Mukoyama et al., “Effects of Sho-saiko-to on hepatocarcinogenesis and 8-hydroxy-2′-deoxyguanosine formation,” Hepatology, vol. 35, no. 5, pp. 1125–1133, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. D. Nakae, Y. Kobayashi, H. Akai et al., “Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine,” Cancer Research, vol. 57, no. 7, pp. 1281–1287, 1997. View at Google Scholar · View at Scopus
  28. R. Shimoda, M. Nagashima, M. Sakamoto et al., “Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis,” Cancer Research, vol. 54, no. 12, pp. 3171–3172, 1994. View at Google Scholar · View at Scopus
  29. M. Tsuchiya, H. Kono, M. Matsuda, H. Fujii, and I. Rusyn, “Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress,” International Journal of Cancer, vol. 123, no. 11, pp. 2503–2511, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus