Table of Contents
ISRN Gastroenterology
Volume 2011, Article ID 394734, 4 pages
http://dx.doi.org/10.5402/2011/394734
Research Article

Barrett's Esophagus in an Area with an Exceptionally Low Prevalence of Helicobacter pylori Infection

1Department of Medicine, Universiti Sains Malaysia, Kubang Kerian, Kota Bahru, 16150 Kelantan, Malaysia
2Department of Pathology, Universiti Sains Malaysia, Kubang Kerian, Kota Bahru, 16150 Kelantan, Malaysia
3Department of Surgery, Universiti Sains Malaysia, Kubang Kerian, Kota Bahru, 16150 Kelantan, Malaysia
4Department of Medicine, Pantai Hospital Kuala Lumpur, 59100 Kuala Lumpur, Malaysia

Received 23 April 2011; Accepted 30 May 2011

Academic Editors: A. Amedei and C. Y. Yeung

Copyright © 2011 Yeong Yeh Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. This study was undertaken to gain an insight into the relationship between Helicobacter pylori (H. pylori) infection, Barrett's esophagus and reflux esophagitis in an area of exceptionally low prevalence of H. pylori infection. Methods. A total of 1895 consecutive upper endoscopies performed between January 2005 and July 2007 were reviewed. 120 cases of columnar-lined esophagus and endoscopic esophagitis were evaluated. H. pylori infection was determined using the urease test and/or histology. Results. The rate of endoscopic esophagitis was 5.49% (80 Malays, 24 non-Malays) while histological reflux esophagitis was found in 3.75% (56 Malays, 15 non-Malays). Barrett's esophagus was present in 0.79% (11 Malays, 4 non-Malays). H. pylori infection was present in 8/120 or 6.67% subjects. Conclusion. The low rate of Barrett's esophagus in this population does not support the hypothesis that the absence of H. pylori infection is more than a minor risk factor for Barrett's esophagus.