Table of Contents
ISRN Organic Chemistry
Volume 2011, Article ID 406427, 7 pages
Research Article

Potassium Hydroxide Impregnated Alumina (KOH-Alumina) as a Recyclable Catalyst for the Solvent-Free Multicomponent Synthesis of Highly Functionalized Substituted Pyridazines and/or Substituted Pyridazin-3(2H)-ones under Microwave Irradiation

Department of Chemistry, North-Eastern Hill University (NEHU), Permanent Campus, Umshing, Mawlai, Shillong 793022, Meghalaya, India

Received 27 January 2011; Accepted 3 March 2011

Academic Editors: G. R. Cook, G. Kirsch, and J. Perez-Castells

Copyright © 2011 Hormi Mecadon and Bekington Myrboh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The work described herein employs potassium hydroxide impregnated alumina (KOH-alumina) as a mild, efficient, and recyclable catalyst for a one-pot solvent-free and environmentally safer synthesis of 3,4,6-triarylpyridazines and some substituted pyridazines from active methylene carbonyl species, 1,2-dicarbonyls, and hydrazine hydrate by microwave (MW) irradiation. The method offers highly convergent, inexpensive, and functionality-tolerable procedure for rapid access to important pyridazine compounds in good yields.