Table of Contents
ISRN Endocrinology
Volume 2011, Article ID 435047, 6 pages
Clinical Study

Glycemic Profiles of Healthy Individuals with Low Fasting Plasma Glucose and HbA1c

1Department of Hygiene and Public Health, School of Medicine, Teikyo University, Kaga 2-11-1, Itabashi, Tokyo 173-8605, Japan
2Faculty of Pharmaceutical Sciences, Teikyo University, Kaga 2-11-1, Itabashi, Tokyo 173-8605, Japan
3Division of Internal Medicine, Nishi-Arai Hospital, Nishiarai honcho 5-7-14, Adachi, Tokyo 123-0845, Japan
4Department of Internal Medicine, Teikyo University Hospital, Kaga 2-11-1, Itabashi, Tokyo 173-8605, Japan

Received 11 October 2011; Accepted 30 October 2011

Academic Editors: W. B. Chan and A. Petryk

Copyright © 2011 Kyoko Nomura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Scant data exists on glucose profile variability in healthy individuals. Twenty-nine healthy subjects without diabetes (86% male; mean age, 38 years) were measured by a CGM system and under real-life conditions. The median percentage of time spent on the blood glucose >7.8 mmol/L for 24 hrs was greater than 10% in both NFG and IFG groups. When subjects were divided into either NFG group (i.e., FPG levels of <5.6 mmol/L; 𝑛 = 2 2 ) or IFG group (FPG levels of 5.6–6.9 mmol/L; 𝑛 = 7 ), all CGM indicators investigated but GRADE scores, including glucose variability measures, monitoring excursions, hyperglycemia, hypoglycemia, and 24-hour AUC, did not differ significantly between the two groups. GRADE score and its euglycemia% were significantly different between the two groups. Among various CGM indicators, GRADE score may be a sensitive indicator to discriminate glucose profiles between subjects with NFG and those with IFG.