Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011, Article ID 436936, 9 pages
Review Article

Immunopathogenesis in Chlamydia trachomatis Infected Women

Department of Infectious Diseases, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy

Received 4 July 2011; Accepted 8 September 2011

Academic Editors: C. L. Haggerty and F. M. Reis

Copyright © 2011 Maria Teresa Mascellino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We examine the Chlamydia trachomatis (Ct) immunopathogenesis on the basis of the complex interaction between host immune response and virulence microorganism factors. Ct infection can be asymptomatic or may produce an inflammation elicited and preserved by reinfections or persistent infections. We discuss the host polymorphisms that, with their anti- or proinflammatory effects, determine the course of the disease. We also took into account the inflammation process following the Chlamydia illness and the role of both CD4 cells producing IFN-γ and CD8 cells with their cytokines production. The crucial role of Ct-hsp60 and the double activity (either damaging or preserving from some kinds of tumors) of anti-Ct-hsp60 antibodies are considered.