Table of Contents 
ISRN Obstetrics and Gynecology
Volume 2011, Article ID 436936, 9 pages
http://dx.doi.org/10.5402/2011/436936
Review Article

Immunopathogenesis in Chlamydia trachomatis Infected Women

Maria Teresa Mascellino, Priscilla Boccia, and Alessandra Oliva

Department of Infectious Diseases, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy

Received 4 July 2011; Accepted 8 September 2011

Academic Editors: C. L. Haggerty and F. M. Reis

Copyright © 2011 Maria Teresa Mascellino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Agrawal, V. Vats, S. Salhan, and A. Mittal, “The mucosal immune response to Chlamydia trachomatis infection of the reproductive tract in women,” Journal of Reproductive Immunology, vol. 83, no. 1-2, pp. 173–178, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Molano, C. J. L. M. Meijer, E. Weiderpass et al., “The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study,” Journal of Infectious Diseases, vol. 191, no. 6, pp. 907–916, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. den Hartog, S. A. Morré, and J. A. Land, “Chlamydia trachomatis-associated tubal factor subfertility: immunogenetic aspects and serological screening,” Human Reproduction Update, vol. 12, no. 6, pp. 719–730, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. R. S. Stephens, “The cellular paradigm of chlamydial pathogenesis,” Trends in Microbiology, vol. 11, no. 1, pp. 44–51, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Darville and T. J. Hiltke, “Pathogenesis of genital tract disease due to Chlamydia trachomatis,” Journal of Infectious Diseases, vol. 201, supplement 2, pp. S114–S125, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. A. W. Horne, S. J. Stock, and A. E. King, “Innate immunity and disorders of the female reproductive tract,” Reproduction, vol. 135, no. 6, pp. 739–749, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Debattista, P. Timms, J. Allan, and J. Allan, “Reduced levels of γ interferon secretion inresponse to chlamydial 60k Da heat shock protein among women with pelvic inflammatorydisease and a history of repeated Chlamydia trachomatis infections,” Immunology Letters, vol. 81, no. 3, pp. 205–210, 2002. View at Google Scholar
  8. M. T. Mascellino, M. R. Ciardi, A. Oliva, F. Cecinato, and L. Borgese, “Chlamydia trachomatis detection in a population of asymptomatic and symptomatic women: correlation with thepresence of serological markers for this infection,” New Microbiologica, vol. 31, no. 2, pp. 249–256, 2008. View at Google Scholar
  9. F. Cappello, E. C. de Macario, V. di Felice, G. Zummo, and A. J. L. Macario, “Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin,” PLoS Pathogens, vol. 5, no. 8, Article ID e1000552, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. C. M. O'Connell, I. A. Ionova, A. J. Quayle, A. Visintin, and R. R. Ingalls, “Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions: evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen,” Journal of Biological Chemistry, vol. 281, no. 3, pp. 1652–1659, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Darville, C. W. Andrews Jr, J. D. Sikes, P. L. Fraley, and R. G. Rank, “Early local cytokine profiles in strains of mice with different outcomes from chlamydial genital tract infection,” Infection and Immunity, vol. 69, no. 6, pp. 3556–3561, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. P. A. Pioli, E. Amiel, T. M. Schaefer, J. E. Connolly, C. R. Wira, and P. M. Guyre, “Differential expression of toll-like receptors 2 and 4 in tissues of the human female reproductive tract,” Infection and Immunity, vol. 72, no. 10, pp. 5799–5806, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Fazeli, C. Bruce, and D. O. Anumba, “Characterization of Toll-like receptors in the female reproductive tract in humans,” Human Reproduction, vol. 20, no. 5, pp. 1372–1378, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Welter-Stahl, D. M. Ojcius, J. Viala et al., “Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum,” Cellular Microbiology, vol. 8, no. 6, pp. 1047–1057, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Ganz, “Antimicrobial polypeptides,” Journal of Leukocyte Biology, vol. 75, no. 1, pp. 34–38, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. O. Wiedow, J. Ludemann, and B. Utecht, “Elafin is a potent inhibitor of proteinase 3,” Biochemical and Biophysical Research Communications, vol. 174, no. 1, pp. 6–10, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. J. V. Fahey and C. R. Wira, “Effect of menstrual status on antibacterial activity and secretory leukocyte protease inhibitor production by human uterine epithelial cells in culture,” Journal of Infectious Diseases, vol. 185, no. 11, pp. 1606–1613, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Ota, K. Shimoya, Q. Zhang et al., “The expression of secretory leukocyte protease inhibitor (SLPI) in the Fallopian tube: SLPI protects the acrosome reaction of sperm from inhibitory effects of elastase,” Human Reproduction, vol. 17, no. 10, pp. 2517–2522, 2002. View at Google Scholar · View at Scopus
  19. M. E. Klotman and T. L. Chang, “Defensins in innate antiviral immunity,” Nature Reviews Immunology, vol. 6, no. 6, pp. 447–456, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. S. J. Stock, R. W. Kelly, S. C. Riley, and A. A. Calder, “Natural antimicrobial production by the amnion,” American Journal of Obstetrics and Gynecology, vol. 196, no. 3, pp. 255.e1–255.e6, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. H. C. Wiesenfeld, S. L. Hillier, M. A. Krohn et al., “Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease,” Obstetrics and Gynecology, vol. 100, no. 3, pp. 456–463, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. M. T. Mascellino, M. Margani, and A. Oliva, “Helicobacter pylori: determinant and markers of virulence,” Disease Markers, vol. 27, no. 3-4, pp. 137–156, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Agrawal, V. Vats, S. Salhan, and A. Mittal, “The mucosal and peripheral immune responses to chlamydial heat shock proteins in women infected with Chlamydia trachomatis,” Clinical and Experimental Immunology, vol. 148, no. 3, pp. 461–467, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Srivastava, R. Jha, S. Salhan, and A. Mittal, “In Infertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-γ, interleukin-10 andtumor necrosis factor-α upon heat shock protein stimulation than fertile women,” Reproductive Biology and Endocrinology, vol. 6, no. 20, 2008. View at Publisher · View at Google Scholar
  25. M. J. Holland, R. L. Bailey, D. J. Conway et al., “T helper type-1 (Th1)/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of Chlamydia trachomatis in subjects with severe trachomatous scarring,” Clinical and Experimental Immunology, vol. 105, no. 3, pp. 429–435, 1996. View at Google Scholar · View at Scopus
  26. T. Darville, C. W. Andrews, J. D. Sikes, P. L. Fraley, L. Braswell, and R. G. Rank, “Mouse strain-dependent chemokine regulation of the genital tract T helper cell type 1 immune response,” Infection and Immunity, vol. 69, no. 12, pp. 7419–7424, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. S. G. Morrison, H. Su, H. D. Caldwell, and R. P. Morrison, “Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4+ T cells but not CD8+ T cells,” Infection and Immunity, vol. 68, no. 12, pp. 6979–6987, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. R. C. Brunham and J. Rey-Ladino, “Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine,” Nature Reviews Immunology, vol. 5, no. 2, pp. 149–161, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. G. R. Burstein, C. A. Gaydos, M. Diener-West, M. R. Howell, J. M. Zenilman, and T. C. Quinn, “Incident Chlamydia trachomatis infections among inner-city adolescent females,” Journal of the American Medical Association, vol. 280, no. 6, pp. 521–526, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Nandakumar, C. W. T. Miller, and U. Kumaraguru, “T regulatory cells: an overview and intervention techniques to modulate allergy outcome,” Clinical and Molecular Allergy, vol. 7, no. 5, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. A. W. Horne, S. J. Stock, and A. E. King, “Innate immunity and disorders of the female reproductive tract,” Reproduction, vol. 135, no. 6, pp. 739–749, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Kanzler, F. J. Barrat, E. M. Hessel, and R. L. Coffman, “Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists,” Nature Medicine, vol. 13, no. 5, pp. 552–559, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Darville, J. M. O'Neill, C. W. Andrews, U. M. Nagarajan, L. Stahl, and D. M. Ojcius, “Tolllikereceptor-2, but not toll-like receptor-4, is essential for development of oviductpathology in chlamydial genital tract infection,” The Journal of Immunology, vol. 171, no. 11, pp. 6187–6197, 2003. View at Google Scholar
  34. C. R. Cohen, K. M. Koochesfahani, A. S. Meier et al., “Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon-γ,” Journal of Infectious Diseases, vol. 192, no. 4, pp. 591–599, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Kimani, I. W. Maclean, J. J. Bwayo et al., “Risk factors for Chlamydia trachomatis pelvic inflammatory disease among sex workers in Nairobi, Kenya,” Journal of Infectious Diseases, vol. 173, no. 6, pp. 1437–1444, 1996. View at Google Scholar · View at Scopus
  36. J. F. Peipert, L. Boardman, J. W. Hogan, J. Sung, and K. H. Mayer, “Laboratory evaluation ofacute upper genital tract infection,” Obstetrics & Gynecology, vol. 87, no. 5, pp. 730–736, 1996. View at Google Scholar
  37. A. Kinnunen, H. Surcel, M. Lehtinen et al., “HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case-control study,” Human Reproduction, vol. 17, no. 8, pp. 2073–2078, 2002. View at Google Scholar · View at Scopus
  38. R. G. Rank, C. Dascher, A. K. Bowlin, and P. M. Bavoil, “Systemic immunization with Hsp60 alters the development of chlamydial ocular disease,” Investigative Ophthalmology and Visual Science, vol. 36, no. 7, pp. 1344–1351, 1995. View at Google Scholar · View at Scopus
  39. P. C. Res, C. G. Schaar, F. C. Breedveld et al., “Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis,” The Lancet, vol. 2, no. 8609, pp. 478–480, 1988. View at Google Scholar · View at Scopus
  40. K. W. Wucherpfennig, J. Newcombe, H. Li, C. Keddy, M. L. Cuzner, and D. A. Hafler, “gd T-cell receptor repertoire in acute multiple sclerosis lesions,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 10, pp. 4588–4592, 1992. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Child, C. Smith, and C. Williams, “Heat shock protein and the double insulin theory for the development of insulin dependent diabetes,” Journal of the Royal Society of Medicine, vol. 86, no. 4, pp. 217–219, 1993. View at Google Scholar · View at Scopus
  42. P. Bavoil, R. S. Stephens, and S. Falkow, “A soluble 60 kilodalton antigen of Chlamydia spp. is a homologue of Escherichia coli GroEL,” Molecular Microbiology, vol. 4, no. 3, pp. 461–469, 1990. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Jakus, A. Neuer, S. Dieterle, A. M. Bongiovanni, and S. S. Witkin, “Antibody to the Chlamydia trachomatis 60 kDa heat shock protein in follicular fluid and in vitro fertilization outcome,” American Journal of Reproductive Immunology, vol. 59, no. 2, pp. 85–89, 2008. View at Google Scholar
  44. A. J. L. Macario and E. C. de Macario, “Sick chaperones, cellular stress, and disease,” New England Journal of Medicine, vol. 353, no. 14, pp. 1489–1501, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. A. J. L. Macario and E. C. de Macario, “Chaperonopathies by defect, excess, or mistake,” Annals of the New York Academy of Sciences, vol. 1113, pp. 178–191, 2007. View at Publisher · View at Google Scholar · View at Scopus