Next Generation Cancer Protection: The Bivalent HPV Vaccine for Females

Figure 3

HPV 16 and 18 prevention will reduce cytologic abnormalities by small amounts [73]. In a screened population, while the greatest prophylactic vaccine protection will be in preventing over 70% of cervical cancers, the absolute numbers of cancers available to prevent are quite small. On the other hand, the estimated 8% reduction in ASCUS and 23% reduction in LSIL will yield a much larger absolute number of women who are prevented from further medical work-up [73]. It is this prevention of further medical follow-up that drives the cost-effectiveness of prophylactic vaccination in screened populations [73].