Table of Contents
ISRN Toxicology
Volume 2011, Article ID 461928, 8 pages
http://dx.doi.org/10.5402/2011/461928
Research Article

Can Diabetes I and Early Blindness Be Prevented Using a Tylenol Combination Which Inhibits Oxidative and Nitrosative Stress?

1Department of Biochemistry and Molecular Pharmacology, Robert C. Byrd Medical Center, West Virginia University Morgantown, WV 26506, USA
2Department of Medicine, Robert C. Byrd Medical Center, West Virginia University Morgantown, WV 26506, USA
3Center for Digestive Disorders at Rush Medical Center, Chicago, IL 60612, USA

Received 26 June 2011; Accepted 7 August 2011

Academic Editors: B. Mandal and M. L. Miranda Fernandes Estevinho

Copyright © 2011 Knox Van Dyke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Since oxidative/nitrosative stress cause diabetes, can we prevent this chemistry generating the disease? Streptozotocin causes diabetes by entering the pancreatic beta cell generating excessive nitric oxide which reacts with oxygen creating a toxin possibly peroxynitrite, dinitrogen trioxide, dinitrogen tetraoxide and so forth. The toxic compounds damage the DNA causing beta cell death. This prevents insulin synthesis, storage and release. By using antioxidant substances that destroy the nitric-oxide-based toxins (e.g., carboxy-PTIO (oxidizes nitric oxide), polyphenolic-quercetin and monophenolic acetaminophen (Tylenol)) which are oxidation and nitration targets can the diabetes I causing toxins in animals be destroyed? Will this tri-drug combination completely prevent the deleterious effects of diabetes namely poor blood glucose control and blindness from cataracts for the entire length of the experiment (one year). These disease reversal experiments were accomplished in rats where the streptozotocin-diabetic effects were completely thwarted. In vitro experiments were accomplished to provide the scientific basis for the experimental results in animals.