Research Article
Multiple Pregnancy after Gonadotropin-Intrauterine Insemination: An Unavoidable Event?
Table 3
Cancellation criteria to prevent high-order multiple pregnancy (≥3 sacs) during gonadotropin-IUI cycles.
| | Clinical pregnancy | Cycles | ≥2 sacs | ≥2 sacs per clinical pregnancy (%) | ≥3 sacs | ≥3 sacs per clinical pregnancy (%) |
| | No. of mature follicles | | | | | | | | 1-2 | 68 | 490 | 15 | 15/68 (22.0%) | 4 | 4/68 (5.8%) | | 3 | 23 | 173 | 3 | 3/23 (13.0%) | 2 | 2/23 (8.6%) | | 4 | 20 | 96 | 6 | 6/20 (30.0%) | 2 | 2/20 (10.0%) | | ≥5 | 8 | 102 | 6 | 6/8 (75.0%) | 3 | 3/8 (37.5%) |
| | Peak E2 (pg/mL) | | | | | | | | ≤800 | 62 | 558 | 11 | 11/62 (17.7%) | 4 | 4/62 (6.4%) | | 801–1000 | 15 | 101 | 5 | 5/15 (33.3%) | 2 | 2/15 (13.3%) | | 1001–1200 | 17 | 69 | 4 | 4/17 (23.5%) | 1 | 1/17 (5.8%) | | 1201–1500 | 13 | 75 | 3 | 3/13 (23.0%) | 3 | 3/13 (23.0%) | | ≥1500 | 12 | 58 | 7 | 7/12 (58.3%) | 1 | 1/12 (8.3%) |
| | Age | | | | | | | | ≤34 | 63 | 338 | 18 | 18/63 (28.6%) | 8 | 8/63 (12.7%) | | 35–37 | 33 | 240 | 8 | 8/33 (24.2%) | 2 | 2/33 (6.0%) | | 38–40 | 16 | 156 | 3 | 3/16 (18.7%) | 0 | 0/20 (0%) | | 41-42 | 4 | 78 | 1 | 1/4 (25.0%) | 1 | 1/4 (25.0%) | | ≥43 | 3 | 49 | 0 | 0/3 (0%) | 0 | 0/3 (0%) |
| | Max. daily gonadotropin dose | | | | | | | | ≥5 | 18 | 194 | 2 | 2/18 (11.1%) | 0 | 0/18 (0%) | | 4 | 17 | 129 | 3 | 3/17 (17.6%) | 2 | 2/17 (11.7%) | | 3 | 32 | 186 | 7 | 7/32 (21.8%) | 4 | 4/32 (12.5% | | ≤2.5 | 52 | 352 | 18 | 18/52 (34.6%) | 5 | 5/52 (9.6%) |
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