Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011 (2011), Article ID 472083, 6 pages
Research Article

Age at Menarche, Menstrual Characteristics, and Risk of Preeclampsia

1Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98104, USA
2Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
3Department of Social and Preventive Medicine, The State University of New York at Buffalo, Buffalo, NY 14214-8001, USA

Received 3 October 2011; Accepted 14 November 2011

Academic Editors: S. Hansson, R. Kimmig, and T. Perez-Medina

Copyright Β© 2011 Dejene F. Abetew et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We examined associations of age at menarche and menstrual characteristics with the risk of preeclampsia among participants ( 𝑛 = 3 , 3 6 5 ) of a pregnancy cohort study. Data were collected using in-person interviews and medical record abstraction. Logistic regression was used to estimate adjusted odds ratio (OR) and 95% confidence interval (95% CI). There was a significant inverse association between age at menarche and risk of preeclampsia ( 𝑃 value for trend < 0.05). Association of long cycle length (>36 days) with higher risk of preeclampsia was present only among women who had prepregnancy body mass index <25 kg/m2 (interaction 𝑃 value = 0.04). Early menarche is associated with higher risk of preeclampsia. Prepregnancy weight may modify associations of long menstrual cycles with risk of preeclampsia.