Table of Contents
ISRN Endocrinology
Volume 2011, Article ID 480656, 5 pages
Research Article

Neurofunctional Evaluation of Young Male Offspring of Rat Dams with Diabetes Induced by Streptozotocin

1Departamento de Obstetrícia, Rua Napoleão de Barros 875, Universidade Federal de São Paulo, 04024-002 São Paulo, SP, Brazil
2Laboratório de Neuropatologia e Neuroproteção, Rua Pedro de Toledo 781, 7 andar, Universidade Federal de São Paulo, 04039-032 São Paulo, SP, Brazil

Received 25 June 2011; Accepted 2 August 2011

Academic Editors: W. B. Chan and T.-H. Tung

Copyright © 2011 Carla Delascio Lopes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetes mellitus (DM) is a complex disease, being one of the most prevalent diseases worldwide. As a consequence, pregnancy-associated diabetes is increasingly common. Given the numerous studies about the influence of diabetes on offspring of diabetic rat dams, the neurological outcome is of outmost importance. This paper aimed at evaluating the neurofunctional performance of young male offspring of rat dams with diabetes induced by streptozotocin. Diabetes was induced in Wistar female rats by streptozotocin administration, while control groups received vehicle injection. At two-month survival period, male offspring from each group were randomized to the water maze Morris test, in order to assess their neurofunctional status. There was no significant difference between the groups as assessed by the Morris water maze test for spatial reference task. Our results point to the need of further investigation on the offspring neurofunctional performance.