Table of Contents
ISRN Gastroenterology
Volume 2011, Article ID 489065, 3 pages
Research Article

Esophagitis in Children with Celiac Disease

1Digestive Diseases, Hepatology and Nutrition Center, Connecticut Children's Medical Center, School of Medicine University of Connecticut, Framington, CT 06030, USA
2Digestive Diseases and Nutrition Center, Women and Children's Hospital of Buffalo, University at Buffalo, NY 14222, USA

Received 19 April 2011; Accepted 24 May 2011

Academic Editor: J.-P. Buts

Copyright © 2011 Wael N. Sayej et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To our knowledge, the occurrence of esophagitis in children with celiac disease (CD) has never been evaluated. The aim of this study is to determine the prevalence of esophagitis in children with CD. Patients and Methods. Between 2003 and 2007, children with biopsy confirmed CD were retrospectively identified. Biopsy reports were reviewed for esophageal inflammation. Biopsy reports of 2218 endoscopies performed during the same period were also evaluated for inflammation. Results. Forty-nine children diagnosed with CD (47% boys). Nineteen of 49 (39%) patients with CD had esophagitis (95% CI 0.23–0.5). Thirty percent of boys and 46% of girls with CD had esophagitis (95% CI 0.12–0.40). Overall, 45% of patients who underwent upper endoscopy had esophagitis. The prevalence of esophagitis in CD (39%) compared to the prevalence of esophagitis (45%) in our practice was not significantly different, ๐‘ƒ = 0 . 2 5 2 6 . Conclusion. There was no difference in the prevalence of esophagitis between children diagnosed with CD at the time of their diagnostic EGD and the prevalence of esophagitis in children without CD. A prospective study to determine whether the esophagitis should be treated with acid suppression or whether the esophagitis heals with the gluten-free diet is warranted.