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ISRN Allergy
Volume 2011 (2011), Article ID 493624, 5 pages
Clinical Study

Predicting the Long-Term Course of Asthma in Wheezing Infants Is Still a Challenge

1Asthma and Allergies Centre, Armand-Trousseau Children Hospital, University Pierre and Marie Curie-Paris 6, Paris, France
2Biostatistics Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France
3Center of Clinical Investigations, Faculty of Medicine, University of Clermont-Ferrand, Clermont-Ferrand, France
4Airborne Allergies in Infants Unit, Department of Pediatrics, CHU-Estaing/University Teaching Hospital of Clermont-Ferrand, Clermont-Ferrand, France

Received 8 May 2011; Accepted 5 June 2011

Academic Editors: D. C. Cara and B. Xu

Copyright © 2011 Flore Amat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. In recurrent wheezing infants, it is important to identify those likely to remain asthmatic in order to propose appropriate long-term management. Objective. To establish predictive factors for persistent asthma at adolescence in a population of recurrent wheezing infants. Methods. Retrospective study of 227 infants. Inclusion criteria were age under 36 months, a history of at least three wheezing episodes assessed via a doctor-led ISAAC questionnaire and a standardized allergy testing programme. At 13 years, active asthma was assessed by questionnaire. Results. Risk factors for asthma persisting into adolescence were allergic sensitization to multiple airborne allergens (OR 4.6, CI-95% (1.9–11.2) 𝑃 = 0 . 0 0 1 ), initial atopic dermatitis (OR 3.4, CI-95% (1.9–6.3) 𝑃 < 0 . 0 0 1 ), severe recurrent wheezing (OR 2.3, CI-95% (1.3–4.2) 𝑃 = 0 . 0 0 7 ), and hypereosinophilia ≥470/mm3 (OR 2.2, CI-95% (1.07–4.7) 𝑃 = 0 . 0 3 3 ). Conclusion. While it is still difficult to predict the long-term course of asthma, atopy remains the major risk factor for persistent asthma.