Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis

Table 2

Comparison between parameters related to class IV segmental (S) versus global (G) proliferative lupus nephritis (LN).

Parameter	Class IV-S LN (𝑛=41)	Class IV-G LN (𝑛=22)
Cases with all glomeruli affected	No	81,82% (18 biopsies); (𝑃<0,0001)
Number (%) of affected glomeruli	473 (76,78%)	327 (91,85%); (𝑃<0,05)
Number (%) of cases with membranoproliferative features	1 of 41 (2,44%)	9 of 22 (40,91%); (𝑃<0,0001)
Percentage of affected glomeruli with fibrinoid necrosis	32, 63% (201 glomeruli)	20, 78% (74 glomeruli); (𝑃<0,01)
Number (%) of biopsies with fibrinoid necrosis in absence of endocapillary proliferation	11 of 29 (37,93%)	0 of 22 (0%)
Number (%) of biopsies with capillary hyaline deposits	9 of 41 (21,95%)	20 of 29 (68,96%); (𝑃<0,01)
Percentage of affected glomeruli with crescents	31,82%	34,55% (𝑃>0,05)
Number (%) of sclerotic glomeruli	174 (28,24%)	85 (23,88%); (𝑃<0,05)