Table of Contents
ISRN Pulmonology
Volume 2011 (2011), Article ID 510860, 11 pages
http://dx.doi.org/10.5402/2011/510860
Research Article

Stochastic Modeling of Particle Deposition in Lungs of Cystic Fibrosis Patients

Division of Physics and Biophysics, Department of Material Sciences and Physics, University of Salzburg Hellbrunner Str. 34, A-5020 Salzburg, Austria

Received 2 March 2011; Accepted 7 April 2011

Academic Editors: A. P. Comellas and A. Mohan

Copyright © 2011 Robert Sturm. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. FitzSimmons, “The changing epidemiology of cystic fibrosis,” Journal of Pediatrics, vol. 122, no. 1, pp. 1–9, 1993. View at Publisher · View at Google Scholar
  2. R. E. Wood, “Treatment of CF lung disease in first two years,” Pediatric Pulmonology, vol. 4, no. 1, pp. 68–70, 1988. View at Google Scholar
  3. J. F. Tomashefski Jr., C. R. Abramowsky, and B. B. Dahms, “The pathology of cystic fibrosis,” in Cystic Fibrosis, P. B. Davis, Ed., pp. 435–489, Marcel Dekker, New York, NY, USA, 1993. View at Google Scholar
  4. D. Reinhardt, M. Götz, R. Krämer, and M. Schöni, Cystische Fibrose, Springer, Berlin, Germany, 2001.
  5. P. B. Davis, “Pathophysiology of the lung disease in cystic fibrosis,” in Cystic Fibrosis, P. B. Davis, Ed., pp. 193–218, Marcel Dekker, New York, NY, USA, 1993. View at Google Scholar
  6. S. V. Turpin and M. R. Knowles, “Treatment of pulmonary disease in patients with cystic fibrosis,” in Cystic Fibrosis, P. B. Davis, Ed., pp. 277–344, Marcel Dekker, New York, NY, USA, 1993. View at Google Scholar
  7. M. W. Konstan and M. Berger, “Infection and inflammation of the lung in cystic fibrosis,” in Cystic Fibrosis, P. B. Davis, Ed., pp. 219–276, Marcel Dekker, New York, NY, USA, 1993. View at Google Scholar
  8. P. J. Anderson, J. D. Blanchard, J. D. Brain, H. A. Feldman, J. J. McNamara, and J. Heyder, “Effect of cystic fibrosis on inhaled aerosol boluses,” American Review of Respiratory Disease, vol. 140, no. 5, pp. 1317–1324, 1989. View at Google Scholar
  9. T. Martonen, I. Katz, and W. Cress, “Aerosol deposition as a function of airway disease: cystic fibrosis,” Pharmaceutical Research, vol. 12, no. 1, pp. 96–102, 1995. View at Google Scholar
  10. R. Winkler-Heil, R. Sturm, and W. Hofmann, “Calculation of therapeutic aerosol deposition in cystic fibrosis patients,” Journal of Aerosol Medicine, vol. 14, no. 4, p. 414, 2001. View at Google Scholar
  11. R. A. Segal, T. B. Martonen, C. S. Kim, and M. Shearer, “Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients,” Inhalation Toxicology, vol. 14, no. 7, pp. 705–720, 2002. View at Publisher · View at Google Scholar
  12. H. Y. Luo, Y. Liu, and X. L. Yang, “Particle deposition in obstructed airways,” Journal of Biomechanics, vol. 40, no. 14, pp. 3096–3104, 2007. View at Publisher · View at Google Scholar
  13. L. Koblinger and W. Hofmann, “Monte Carlo modeling of aerosol deposition in human lungs—part I: simulation of particle transport in a stochastic lung structure,” Journal of Aerosol Science, vol. 21, no. 5, pp. 661–674, 1990. View at Google Scholar
  14. B. Alföldy, R. Sturm, I. Balásházy, W. Hofmann, and I. Boros, “Deposition distribution of therapeutic aerosols in healthy and asthmatic human lungs,” in Proceedings of the International Aerosol Conference, pp. 1050–1051, Taipei, Taiwan, 2002.
  15. H. L. Chua, G. G. Collis, A. M. Newbury et al., “The influence of age on aerosol deposition in children with cystic fibrosis,” European Respiratory Journal, vol. 7, no. 12, pp. 2185–2191, 1994. View at Publisher · View at Google Scholar
  16. International Commission on Radiological Protection (ICRP), Human Respiratory Tract Model for Radiological Protection, ICRP Publication 66. Annals of the ICRP 24, Pergamon Press, Oxford, UK, 1994.
  17. J. L. Mauderly and F. F. Hahn, Advances in Veterinary Science and Comparative Medicine: The Respiratory System, vol. 26, Academic Press, New York, NY, USA, 1982.
  18. O. G. Raabe, H. C. Yeh, G. M. Schum, and R. F. Phalen, “Tracheobronchial geometry: human, dog, rat, hamster,” Tech. Rep. LF-53, Lovelace Foundation, Albuquerque, NM, USA, 1976. View at Google Scholar
  19. L. Koblinger and W. Hofmann, “Analysis of human lung morphometric data for stochastic aerosol deposition calculations,” Physics in Medicine and Biology, vol. 30, no. 6, pp. 541–556, 1985. View at Publisher · View at Google Scholar
  20. M. King, H. K. Chang, and M. E. Weber, “Resistance of mucus-lined tubes to steady and oscillatory airflow,” Journal of Applied Physiology: Respiratory Environmental and Exercise Physiology, vol. 52, no. 5, pp. 1172–1176, 1982. View at Google Scholar
  21. L. Morrison, R. Ball, S. P. Conway, and K. G. Brownlee, “Airway resistance measurements in children with cystic fibrosis,” Physiotherapy, vol. 89, no. 11, pp. 629–636, 2003. View at Google Scholar
  22. D. K. Meyerholz, D. A. Stoltz, E. Namati et al., “Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children,” American Journal of Respiratory and Critical Care Medicine, vol. 182, no. 10, pp. 1251–1261, 2010. View at Publisher · View at Google Scholar
  23. R. Sturm and W. Hofmann, “Stochastic simulation of alveolar particle deposition in lungs affected by different types of emphysema,” Journal of Aerosol Medicine, vol. 17, no. 4, pp. 357–372, 2004. View at Publisher · View at Google Scholar
  24. G. Dockter, H. Lindemann, and B. Tümmler, Mukoviszidose, Thieme, Stuttgart, Germany, 2000.
  25. J. Milic-Emili, J. A. M. Henderson, M. B. Dolovich, D. Trop, and K. Kaneko, “Regional distribution of inspired gas in the lung,” Journal of Applied Physiology, vol. 21, no. 3, pp. 749–759, 1966. View at Google Scholar
  26. S. G. Devadason, M. L. Everard, C. MacEarlan et al., “Lung deposition from the Turbuhaler® in children with cystic fibrosis,” European Respiratory Journal, vol. 10, no. 9, pp. 2023–2028, 1997. View at Publisher · View at Google Scholar
  27. W. Hofmann and L. Koblinger, “Monte Carlo modeling of aerosol deposition in human lungs—part III: comparison with experimental data,” Journal of Aerosol Science, vol. 23, no. 1, pp. 51–63, 1992. View at Google Scholar
  28. A. J. Wardlaw, Asthma, Bios Scientific Publishers, Oxford, UK, 1993.
  29. J. S. Brown, K. L. Zeman, and W. D. Bennett, “Ultrafine particle deposition and clearance in the healthy and obstructed lung,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 9, pp. 1240–1247, 2002. View at Publisher · View at Google Scholar
  30. J. S. Brown, K. L. Zeman, and W. D. Bennett, “Regional deposition of coarse particles and ventilation distribution in healthy subjects and patients with cystic fibrosis,” Journal of Aerosol Medicine, vol. 14, no. 4, pp. 443–454, 2001. View at Google Scholar
  31. T. B. Martonen, R. C. Graham, and W. Hofmann, “Human subject age and activity level: factors addressed in a biomathematical deposition program for extrapolation modeling,” Health Physics, vol. 57, no. 1, pp. 49–59, 1989. View at Google Scholar
  32. E. R. Weibel, Morphometry of the Human Lung, Springer, Berlin, Germany, 1963.