Table of Contents
ISRN Vascular Medicine
Volume 2011, Article ID 513503, 4 pages
Review Article

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Department of Vascular Surgery, Saint George Hospital, University Medical Center, University of Balamand, Youssef Sursock Street, P.O. Box 166378, Achrafieh, Beirut 1100 2807, Lebanon

Received 9 August 2011; Accepted 20 September 2011

Academic Editors: J. K. Raines and C. Zaragoza

Copyright © 2011 Raghid Kreidy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Post-thrombotic syndrome is an important chronic complication of deep vein thrombosis. This syndrome can be debilitating to patients and has a major economic impact on health care services. The pathophysiology of post-thrombotic syndrome is currently incompletely understood. Because therapeutic options for post-thrombotic syndrome are extremely limited and results are often disappointing, recognizing of the pathophysiology and risk factors of this syndrome is essential to prevent the disabling consequences of this disease. The present paper focuses on risk determinants of post-thrombotic syndrome after deep vein thrombosis. The contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis of this syndrome is reviewed and discussed in details.