Table of Contents
ISRN Vascular Medicine
Volume 2011 (2011), Article ID 513503, 4 pages
http://dx.doi.org/10.5402/2011/513503
Review Article

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Department of Vascular Surgery, Saint George Hospital, University Medical Center, University of Balamand, Youssef Sursock Street, P.O. Box 166378, Achrafieh, Beirut 1100 2807, Lebanon

Received 9 August 2011; Accepted 20 September 2011

Academic Editors: J. K. Raines and C. Zaragoza

Copyright © 2011 Raghid Kreidy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. A. Naess, S. C. Christiansen, P. Romundstud et al., “Incidence and mortality of venous thrombosis,” Journal of Thrombosis, vol. 5, no. 4, pp. 692–699, 2007. View at Google Scholar
  2. J. Avorn and W. C. Winkelmayer, “Comparing the costs, risks, and benefits of competing strategies for the primary prevention of venous thromboembolism,” Circulation, vol. 110, supplement 1, pp. IV25–IV32, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. R. D. Hull, G. F. Pineo, and G. E. Raskob, “The economic impact of treating deep vein thrombosis with low- molecular-weight heparin: outcome of therapy and health economy aspects,” Haemostasis, vol. 28, supplement 3, pp. 8–16, 1998. View at Google Scholar
  4. D. J. Lindner, J. M. Edwards, E. S. Phinney, L. M. Taylor, and J. M. Porter, “Long—term hemodynamic and clinical sequelae of lower extremity deep vein thrombosis,” Journal of Vascular Surgery, vol. 4, no. 5, pp. 436–442, 1986. View at Google Scholar · View at Scopus
  5. P. Prandoni, S. Villalta, P. Polistena, E. Bernardi, A. Cogo, and A. Girolami, “Symptomatic deep-vein thrombosis and the post-thrombotic syndrome,” Haematologica, vol. 80, supplement 2, pp. 42–48, 1995. View at Google Scholar · View at Scopus
  6. D. E. Strandness, Y. Langlois, M. Cramer, A. Randlett, and B. L. Thiele, “Long-term sequelae of acute venous thrombosis,” Journal of the American Medical Association, vol. 250, no. 10, pp. 1289–1292, 1983. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Prandoni, A. W. A. Lensing, A. Cogo et al., “The long-term clinical course of acute deep venous thrombosis,” Annals of Internal Medicine, vol. 125, no. 1, pp. 1–7, 1996. View at Google Scholar · View at Scopus
  8. M. Monreal, A. Martorell, J. M. Callejas et al., “Venographic assessment of deep vein thrombosis and risk of developing post-thrombotic syndrome: a prospective study,” Journal of Internal Medicine, vol. 233, no. 3, pp. 233–238, 1993. View at Google Scholar · View at Scopus
  9. O. Nelzen, D. Bergqvist, A. Lindhagen, and T. Hallbook, “Chronic leg ulcers: an underestimated problem in primary health care among elderly patients,” Journal of Epidemiology and Community Health, vol. 45, no. 3, pp. 184–187, 1991. View at Google Scholar · View at Scopus
  10. O. Nelzen, D. Bergqvist, and A. Lindhagen, “Leg ulcer etiology: a cross sectional population study,” Journal of Vascular Surgery, vol. 14, no. 4, pp. 557–564, 1991. View at Publisher · View at Google Scholar · View at Scopus
  11. F. R. Rosendaal, “Venous thrombosis: a multicausal disease,” The Lancet, vol. 353, no. 9159, pp. 1167–1173, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. C. V. Ruckley, “Socioeconomic impact of chronic venous insufficiency and leg ulcers,” Angiology, vol. 48, no. 1, pp. 67–69, 1997. View at Google Scholar · View at Scopus
  13. M. McGuckin, R. Waterman, J. Brooks et al., “Validation of venous leg ulcer guidelines in the United States and United Kingdom,” American Journal of Surgery, vol. 183, no. 2, pp. 132–137, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Eichlisberger, M. T. Widmer, B. Frauchiger, L. K. Widmer, and K. Jager, “On the incidence of the postthrombotic syndrome,” Wiener Medizinische Wochenschrift, vol. 144, no. 10-11, pp. 192–195, 1994. View at Google Scholar · View at Scopus
  15. S. R. Kahn, “The post-thrombotic syndrome,” Hematology/American Society of Hematology Education Program, vol. 2010, pp. 216–220, 2010. View at Google Scholar
  16. S. Reich-Schupke, P. Altmeyer, and M. Stucker, “What do we know about post-thrombotic syndrome? Current status of post-thrombotic syndrome in adults,” Journal der Deutschen Dermatologischen Gesellschaft, vol. 8, no. 2, pp. 81–87, 2010. View at Google Scholar
  17. B. F. Johnson, R. A. Manzo, R. O. Bergelin, and D. E. Strandness, “Relationship betweenchanges in the deep venous system and the development of the post-thromboticsyndrome after an acute episode of lower limb deep vein thrombosis. A one- to six-year follow-up,” Journal of Vascular Surgery, vol. 21, no. 2, pp. 307–313, 1995. View at Google Scholar
  18. N. Labropoulos, T. Waggoner, W. Sammis, S. Samali, and P. J. Pappas, “The effect of venous thrombus location and extent on the development of post-thrombotic signs and symptoms,” Journal of Vascular Surgery, vol. 48, no. 2, pp. 407–412, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. S. Vedantham, “Valvular dysfunction and venous obstruction in the post-thrombotic syndrome,” Thrombosis Research, vol. 123, no. 4, pp. S62–S65, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. M. H. Meissner, T. W. Wakefield, E. Ascher et al., “Acute venous disease: venous thrombosis and venous trauma,” Journal of Vascular Surgery, vol. 46, supplement 6, pp. S25–S53, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. M. T. Caps, R. A. Manzo, R. O. Bergelin, M. H. Meissner, and D. E. Strandness Jr., “Venous valvular reflux in veins not involved at the time of acute deep vein thrombosis,” Journal of Vascular Surgery, vol. 22, no. 5, pp. 524–531, 1995. View at Publisher · View at Google Scholar
  22. A. Markel, R. A. Manzo, R. O. Bergelin, and D. E. Strandness Jr., “Valvular reflux after deep vein thrombosis: incidence and time of occurrence,” Journal of Vascular Surgery, vol. 15, no. 2, pp. 377–384, 1992. View at Google Scholar · View at Scopus
  23. L. A. Killewich, G. R. Bedford, K. W. Beach, and D. E. Strandness Jr., “Spontaneous lysis of deep venous thrombi: rate and outcome,” Journal of Vascular Surgery, vol. 9, no. 1, pp. 89–97, 1989. View at Google Scholar · View at Scopus
  24. S. Raju, R. K. Fredericks, C. A. Hudson, T. Fountain, P. N. Neglen, and M. Devidas, “Venous valve station changes in “primary” and postthrombotic reflux: an analysis of 149 cases,” Annals of Vascular Surgery, vol. 14, no. 3, pp. 193–199, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. M. H. Meissner, R. A. Manzo, R. O. Bergelin, A. Markel, and D. E. Strandness, “Deep venous insufficiency: the relationship between lysis and subsequent reflux,” Journal of Vascular Surgery, vol. 18, no. 4, pp. 596–608, 1993. View at Google Scholar · View at Scopus
  26. S. Ziegler, M. Schillinger, T. H. Maca, and E. Minar, “Post-thrombotic syndrome after primary event of deep venous thrombosis 10 to 20 years ago,” Thrombosis Research, vol. 101, no. 2, pp. 23–33, 2001. View at Publisher · View at Google Scholar
  27. M. Stain, V. Schonauer, E. Minar et al., “The post-thrombotic syndrome: risk factors and impact on the course of thrombotic disease,” Journal of Thrombosis and Haemostasis, vol. 3, no. 12, pp. 2671–2676, 2005. View at Publisher · View at Google Scholar · View at PubMed
  28. I. Lopez-Azkarreta, S. Reus, P. Marco et al., “Prospective study of the risk factors for the development of post-thrombotic syndrome after proximal deep venous thrombosis,” Medicina Clinica, vol. 125, no. 1, pp. 1–4, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. N. A. Gooley and D. S. Sumner, “Relationship of venous reflux to the site of venous valvular incompetence: implications for venous reconstructive surgery,” Journal of Vascular Surgery, vol. 7, no. 1, pp. 50–59, 1988. View at Google Scholar · View at Scopus
  30. S. Rosfors, L. O. Lamke, E. Nordstrom, and S. Bygdeman, “Severity and location of venous valvular insufficiency: the importance of distal valve function,” Acta Chirurgica Scandinavica, vol. 156, no. 10, pp. 689–694, 1990. View at Google Scholar · View at Scopus
  31. P. S. van Bemmelen, G. Bedford, K. Beach, and D. E. Strandness Jr., “Status of the valves in the superficial and deep venous system in chronic venous disease,” Surgery, vol. 109, no. 6, pp. 730–734, 1991. View at Google Scholar · View at Scopus
  32. M. H. Meissner, M. T. Caps, B. K. Zierler et al., “Determinants of chronic venous disease after acute deep venous thrombosis,” Journal of Vascular Surgery, vol. 28, no. 5, pp. 826–833, 1998. View at Google Scholar · View at Scopus
  33. P. Prandoni, A. W. A. Lensing, and M. R. Prins, “Long-term outcomes after deep venous thrombosis of the lower extremities,” Vascular Medicine, vol. 3, no. 1, pp. 57–60, 1998. View at Google Scholar · View at Scopus
  34. A. A. Ashrani and J. A. Heit, “Incidence and cost burden of post-thrombotic syndrome,” Journal of Thrombosis and Thrombolysis, vol. 28, no. 4, pp. 465–476, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. S. R. Kahn, “The post-thrombotic syndrome,” Thrombosis Research, vol. 127, supplement 3, pp. 589–592, 2011. View at Google Scholar
  36. T. Baglin, R. Luddington, K. Brown, and C. Baglin, “Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study,” The Lancet, vol. 362, no. 9383, pp. 523–526, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. J. A. Heit, D. N. Mohr, M. D. Silverstein, T. M. Petterson, W. M. O'Fallon, and L. J. Melton, “Predictors of recurrence after deep vein thrombosis and pulmonary embolism: a population-based cohort study,” Archives of Internal Medicine, vol. 160, no. 6, pp. 761–768, 2000. View at Google Scholar · View at Scopus
  38. M. T. Betancourt and M. A. Rodger, “Risk stratification for recurrent venous thromboembolism in unprovoked venous thromboembolism's patients,” Acta Chirurgica Belgica, vol. 107, no. 6, pp. 636–640, 2007. View at Google Scholar · View at Scopus
  39. N. Labropoulos, J. Jen, H. Jen, A. P. Gasparis, and A. K. Tassiopoulos, “Recurrent deep vein thrombosis: long-term incidence and natural history,” Annals of Surgery, vol. 251, no. 4, pp. 749–753, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. M. Cushman, “Inherited risk factors for venous thrombosis,” Hematology, pp. 452–457, 2005. View at Google Scholar
  41. A. Marchiori, L. Mosena, M. H. Prins, and P. Prandoni, “The risk of recurrent venousthromboembolism among heterozygous carriers of factor V—leiden orprothrombin G 20210A mutation . A systemic review of prospective studies,” Hematologica, vol. 92, no. 8, pp. 1107–1110, 2007. View at Google Scholar
  42. C. Kearon, “Natural history of venous thromboembolism,” Circulation, vol. 107, no. 23, supplement 1, pp. 122–130, 2003. View at Google Scholar
  43. S. Crisan, S. Vesa, C. Pestrea et al., “Chronic thrombotic scarring in patients with acute deep venous thrombosis of the lower extremities,” Medical Ultrasonography, vol. 12, no. 2, pp. 114–119, 2010. View at Google Scholar
  44. M. H. Meissner, M. T. Caps, R. O. Bergelin, R. A. Manzo, and D. E. Strandness Jr., “Propagation, rethrombosis and new thrombus formation after acute deep venous thrombosis,” Journal of Vascular Surgery, vol. 22, no. 5, pp. 558–567, 1995. View at Publisher · View at Google Scholar
  45. R. J. Beyth, A. M. Cohen, and C. S. Landefeld, “Long-term outcomes of deep-vein thrombosis,” Archives of Internal Medicine, vol. 155, no. 10, pp. 1031–1037, 1995. View at Google Scholar · View at Scopus
  46. L. Spiezia, E. Campello, E. Giolo, S. Villalta, and P. Prandoni, “Thrombophilia and the risk of post-thrombotic syndrome: retrospective cohort observation,” Journal of Thrombosis and Haemostasis, vol. 8, no. 1, pp. 211–213, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. A. Delluc, C. Gouedard, L. De Saint Martin et al., “Incidence, risk factors and skin manifestations of post-thrombotic syndrome: a four-year follow-up of patients included in the EDITH study,” Revue de Medecine Interne, vol. 31, no. 11, pp. 729–734, 2010. View at Publisher · View at Google Scholar · View at PubMed
  48. Y. Gaber, H. J. Siemens, and W. Schmeller, “Resistance to activated protein C due to factor V Leiden mutation: high prevalence in patients with post-thrombotic leg ulcers,” British Journal of Dermatology, vol. 144, no. 3, pp. 546–548, 2001. View at Publisher · View at Google Scholar · View at Scopus
  49. L. Spezia, D. Tormene, R. Pesavento, L. Salmaso, P. Simioni, and P. Prandoni, “Thrombophilia as a predictor of persistent residual venous thrombosis,” Hematologica, vol. 93, no. 3, pp. 479–480, 2008. View at Google Scholar
  50. J. A. Gonzalez-Fajardo, M. Martin-Pedrosa, J. Castrodeza, S. Tamames, and C. Vaquero-Puerta, “Effect of the anticoagulant therapy in the incidence of post-thrombotic syndrome and recurrent thromboembolism: comparative study of enoxaparin versus coumarin,” Journal of Vascular Surgery, vol. 48, no. 4, pp. 953–959, 2008. View at Publisher · View at Google Scholar · View at PubMed