Table of Contents
ISRN Toxicology
Volume 2011, Article ID 515724, 9 pages
http://dx.doi.org/10.5402/2011/515724
Research Article

A Novel Approach for a Toxicity Prediction Model of Environmental Pollutants by Using a Quantitative Structure-Activity Relationship Method Based on Toxicogenomics

1Energy and Environment Research Division, Japan Automobile Research Institute, 2530 Karima, Tsukuba, Ibaraki 305-0822, Japan
2Graduate School of Science and Technology, Niigata University, 8050 Ikarashi-2, Nishi-ku, Niigata 950-2181, Japan

Received 5 April 2011; Accepted 30 April 2011

Academic Editors: P. Scheepers and M. Valverde

Copyright © 2011 Junichi Hosoya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. W. Dockery, C. A. Pope, X. Xu et al., “An association between air pollution and mortality in six U.S. cities,” New England Journal of Medicine, vol. 329, no. 24, pp. 1753–1759, 1993. View at Publisher · View at Google Scholar · View at PubMed
  2. C. A. Pope III, M. J. Thun, M. M. Namboodiri et al., “Particulate air pollution as a predictor of mortality in a prospective study of U.S. Adults,” American Journal of Respiratory and Critical Care Medicine, vol. 151, no. 3 I, pp. 669–674, 1995. View at Google Scholar
  3. “HEI, The Advanced Collaborative Emissions Study(ACES),” Project Plan for Emission Characterization and Health Effects Assessment, Health Effects Institute, Boston, Mass, USA, 2006.
  4. S. Koizumi, “Application of DNA microarrays in occupational health research,” Journal of Occupational Health, vol. 46, no. 1, pp. 20–25, 2004. View at Publisher · View at Google Scholar
  5. H. Yamada and S. Koizumi, “DNA microarray analysis of human gene expression induced by a non-lethal dose of cadmium,” Industrial Health, vol. 40, no. 2, pp. 159–166, 2002. View at Google Scholar
  6. S. Koizumi and H. Yamada, “DNA microarray analysis of altered gene expression in cadmium-exposed human cells,” Journal of Occupational Health, vol. 45, no. 6, pp. 331–334, 2003. View at Publisher · View at Google Scholar
  7. C. Hansch, D. Hoekman, A. Leo, L. Zhang, and P. Li, “The expanding role of quantitative structure-activity relationships (QSAR) in toxicology,” Toxicology Letters, vol. 79, no. 1–3, pp. 45–53, 1995. View at Publisher · View at Google Scholar
  8. T. W. Schultz and M. T. Cronin, “Essential and desirable characteristics of ecotoxicity quantitative structure-activity relationships,” Environmental Toxicology and Chemistry, vol. 22, no. 3, pp. 599–607, 2003. View at Publisher · View at Google Scholar
  9. M. T. Cronin, A. O. Aptula, J. C. Duffy et al., “Comparative assessment of methods to develop QSARs for the prediction of the toxicity of phenols to Tetrahymena pyriformis,” Chemosphere, vol. 49, no. 10, pp. 1201–1221, 2002. View at Publisher · View at Google Scholar
  10. D. S. Huang, T. J. Whang, F. C. Cheng et al., “Toxicity assessment of mono-substituted benzenes and phenols using a Pseudomonas initial oxygen uptake assay,” Environmental Toxicology and Chemistry, vol. 24, no. 2, pp. 253–260, 2005. View at Publisher · View at Google Scholar
  11. P. Mazzatorta, L. A. Tran, B. Schilter, and M. Grigorov, “Integration of structure-Activity relationship and artificial intelligence systems to improve in silico prediction of Ames test mutagenicity,” Journal of Chemical Information and Modeling, vol. 47, no. 1, pp. 34–38, 2007. View at Publisher · View at Google Scholar · View at PubMed
  12. M. Dybdahl, L. Risom, J. Bornholdt, H. Autrup, S. Loft, and H. Wallin, “Inflammatory and genotoxic effects of diesel particles in vitro and in vivo,” Mutation Research, vol. 562, no. 1-2, pp. 119–131, 2004. View at Publisher · View at Google Scholar · View at PubMed
  13. E. K. Ahn, H. K. Yoon, B. K. Jee et al., “COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo,” Toxicology Letters, vol. 176, no. 3, pp. 178–187, 2008. View at Publisher · View at Google Scholar · View at PubMed
  14. H. Takano, R. Yanagisawa, T. Ichinose et al., “Diesel exhaust particles enhance lung injury related to bacterial endotoxin through expression of proinflammatory cytokines, chemokines, and intercellular adhesion molecule-1,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 9, pp. 1329–1335, 2002. View at Publisher · View at Google Scholar
  15. Y. Miyabara, H. Takano, T. Ichinose, H. B. Lim, and M. Sagai, “Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 4, pp. 1138–1144, 1998. View at Google Scholar
  16. Y. Miyabara, T. Ichinose, H. Takano, H. B. Lim, and M. Sagai, “Effects of diesel exhaust on allergic airway inflammation in mice,” Journal of Allergy and Clinical Immunology, vol. 102, no. 5, pp. 805–812, 1998. View at Google Scholar
  17. L. M. Teran and D. E. Davies, “The chemokines: their potential role in allergic inflammation,” Clinical and Experimental Allergy, vol. 26, no. 9, pp. 1005–1019, 1996. View at Google Scholar
  18. J. E. Pease and I. Sabroe, “The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy,” American Journal of Respiratory Medicine, vol. 1, no. 1, pp. 19–25, 2002. View at Google Scholar
  19. M. Mathiesen, E. K. Pedersen, O. Bjørseth, K. W. Egeberg, and T. Syversen, “Heating of indoor dust causes reduction in its ability to stimulate release of IL-8 and TNFalpha in vitro compared to non-heated dust,” Indoor Air, vol. 14, no. 4, pp. 226–234, 2004. View at Publisher · View at Google Scholar · View at PubMed
  20. C. Monn, R. Naef, and T. Koller, “Reactions of macrophages exposed to particles <10  micrometers,” Environmental Research, vol. 91, no. 1, pp. 35–44, 2003. View at Publisher · View at Google Scholar
  21. C. Monn and S. Becker, “Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM2.5) and coarse particles (PM10-2.5) in outdoor and indoor air,” Toxicology and Applied Pharmacology, vol. 155, no. 3, pp. 245–252, 1999. View at Publisher · View at Google Scholar · View at PubMed
  22. S. F. Van Eeden, W. C. Tan, T. Suwa et al., “Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)),” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 5, pp. 826–830, 2001. View at Google Scholar
  23. S. S. Salvi, C. Nordenhall, A. Blomberg et al., “Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways,” American Journal of Respiratory and Critical Care Medicine, vol. 161, no. 2 I, pp. 550–557, 2000. View at Google Scholar
  24. H. Y. Nam, E. K. Ahn, H. J. Kim et al., “Diesel exhaust particles increase IL-1beta-induced human beta-defensin expression via NF-kappaB-mediated pathway in human lung epithelial cells,” Particle and Fibre Toxicology, vol. 3, article 9, 2006. View at Publisher · View at Google Scholar · View at PubMed
  25. G. Mazzarella, F. Ferraraccio, M. V. Prati et al., “Effects of diesel exhaust particles on human lung epithelial cells: an in vitro study,” Respiratory Medicine, vol. 101, no. 6, pp. 1155–1162, 2007. View at Publisher · View at Google Scholar · View at PubMed
  26. X. H. Pei, Y. Nakanishi, H. Inoue, K. Takayama, F. Bai, and N. Hara, “Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line,” Cytokine, vol. 19, no. 5, pp. 236–241, 2002. View at Publisher · View at Google Scholar
  27. H. Bömmel, M. Haake, P. Luft et al., “The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin,” International Immunopharmacology, vol. 3, no. 10-11, pp. 1371–1379, 2003. View at Publisher · View at Google Scholar · View at PubMed
  28. C. A. Lipinski, F. Lombardo, B. W. Dominy, and P. J. Feeney, “Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings,” Advanced Drug Delivery Reviews, vol. 46, no. 1-3, pp. 3–26, 2001. View at Publisher · View at Google Scholar
  29. A. Harada, N. Sekido, K. Kuno et al., “Expression of recombinant rabbit IL-8 in Escherichia coli and establishment of the essential involvement of IL-8 in recruiting neutrophils into lipopolysaccharide-induced inflammatory site of rabbit skin,” International Immunology, vol. 5, no. 6, pp. 681–690, 1993. View at Google Scholar
  30. I. Rahman, “Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases,” Journal of Biochemistry and Molecular Biology, vol. 36, no. 1, pp. 95–109, 2003. View at Google Scholar
  31. I. Lehmann, C. Röder-Stolinski, K. Nieber, and G. Fischäder, “In vitro models for the assessment of inflammatory and immuno-modulatory effects of the volatile organic compound chlorobenzene,” Experimental and Toxicologic Pathology, vol. 60, no. 2-3, pp. 185–193, 2008. View at Publisher · View at Google Scholar · View at PubMed
  32. Y. F. Yang, J. Y. Hsu, L. S. Fu, Y. S. Weng, and J. J. Chu, “Asthma drugs counter-regulate interleukin-8 release stimulated by sodium sulfite in an A549 cell line,” Journal of Asthma, vol. 46, no. 3, pp. 238–243, 2009. View at Publisher · View at Google Scholar · View at PubMed
  33. J. Milara, M. Mata, M. D. Mauricio, E. Donet, E. J. Morcillo, and J. Cortijo, “Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis,” European Journal of Pharmacology, vol. 609, no. 1–3, pp. 132–139, 2009. View at Publisher · View at Google Scholar · View at PubMed
  34. M. Bianchi, G. Fantuzzi, R. Bertini, L. Perin, M. Salmona, and P. Ghezzi, “The pneumotoxicant paraquat induces IL-8 mRNA in human mononuclear cells and pulmonary epithelial cells,” Cytokine, vol. 5, no. 5, pp. 525–530, 1993. View at Publisher · View at Google Scholar
  35. M. Stoeck, M. Schäfer, H. P. Hofmann, and V. Gekeler, “Dexamethasone and cyclosporin A do not inhibit interleukin-15 expression in the human lung carcinoma cell line A549,” European Cytokine Network, vol. 11, no. 3, pp. 414–419, 2000. View at Google Scholar
  36. S. L. Yeh, H. M. Wang, P. Y. Chen, and T. C. Wu, “Interactions of beta-carotene and flavonoids on the secretion of pro-inflammatory mediators in an in vitro system,” Chemico-Biological Interactions, vol. 179, no. 2-3, pp. 386–393, 2009. View at Publisher · View at Google Scholar · View at PubMed
  37. R. Aneja, K. Odoms, A. G. Denenberg, and H. R. Wong, “Theaflavin, a black tea extract, is a novel anti-inflammatory compound,” Critical Care Medicine, vol. 32, no. 10, pp. 2097–2103, 2004. View at Publisher · View at Google Scholar
  38. S. Ghosh, M. J. May, and E. B. Kopp, “NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses,” Annual Review of Immunology, vol. 16, pp. 225–260, 1998. View at Publisher · View at Google Scholar · View at PubMed
  39. P. M. Bork, M. L. Schmitz, M. Kuhnt, C. Escher, and M. Heinrich, “Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB,” FEBS Letters, vol. 402, no. 1, pp. 85–90, 1997. View at Publisher · View at Google Scholar
  40. S. P. Hehner, M. Heinrich, P. M. Bork et al., “Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta,” Journal of Biological Chemistry, vol. 273, no. 3, pp. 1288–1297, 1998. View at Publisher · View at Google Scholar
  41. R. L. Mazor, I. Y. Menendez, M. A. Ryan, M. A. Fiedler, and H. R. Wong, “Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium,” Cytokine, vol. 12, no. 3, pp. 239–245, 2000. View at Publisher · View at Google Scholar · View at PubMed
  42. U.S. EPA, “Strategic plan for evaluating the toxicity of chemicals,” EPA 100/K-09/001, U.S. Environmental Protection, Washington, DC, USA, 2009. View at Google Scholar