Feasibility of Repurposing the Polyanionic Microbicide, PPCM, for Prophylaxis against HIV Transmission during ART

Figure 6

PPCM decreases infectivity of semen infected in vitro with HIV. Details of treating whole semen with HIV-1 (Bal) followed by PPCM exposure and measurement of viral titer after culturing in PBMCs are presented in Section 2. Data are reported as mean viral titer (ng/mL of p24, (a): or copies/mL viral RNA, (b)) for each condition (note Log scale). Error bars are SEM (𝑁=3). ^A-CValues with different letter designations are different (𝑃<.01, Newman-Keuls multiple range test).

(a)

(b)