Table of Contents
ISRN Oncology
Volume 2011, Article ID 539503, 7 pages
http://dx.doi.org/10.5402/2011/539503
Research Article

Predictors of Nonsentinel Nodal Involvement to Aid Intraoperative Decision Making in Breast Cancer Patients with Positive Sentinel Lymph Nodes

1Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
2Department of Pathology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
3Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore, 8 College Road, Singapore 169857

Received 27 April 2011; Accepted 27 June 2011

Academic Editors: A. E. Pinto, H. Rizos, E. Sueoka, and A. H. Wolfson

Copyright © 2011 Ern Yu Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Up to 60% of patients with a positive sentinel lymph node (SLN) have no additional nodal involvement and do not benefit from completion axillary lymph node dissection (ALND). We aim to identify factors predicting for non-SLN involvement and to validate the MSKCC nomogram and Tenon score in our population. Methods. Retrospective review was performed of 110 consecutive patients with positive SLNs who underwent ALND over an 8-year period. Results. Fifty patients (45%) had non-SLN involvement. Non-SLN involvement correlated positively with the number of positive SLNs (P=0.04), macrometastasis (P=0.01), and inversely with the total number of SLNs harvested (P=0.03). The MSKCC nomogram and Tenon score both failed to perform as previously reported. Conclusions. The MSKCC nomogram and Tenon score have limited value in our practice. Instead, we identified three independent predictors, which are more relevant in guiding the intraoperative decision for ALND.