Metastatic Bladder Cancer: A Review of Current Management

Table 1

Summary of literature related to first-line chemotherapy for metastatic bladder cancer.

	Sternberg et al. [7]	Sternberg et al. [7]	Von der Masse et al. [8]	Von der Masse et al. [8]	Ecke et al. [9]	Bellmunt et al. [10]	Bellmunt et al. [10]	Dogliotti et al. [11]	Dogliotti et al. [11]	Dreicer et al. [12]	Dreicer et al. [12]
Chemotherapy regime	MVAC	HD-MVAC + GCSF	MVAC	GC	GC + Pac	MVAC	M-CAVI	GC	Gem-Carbo	MVAC	Carbo-Pac
Response Rate (%)	58	72	45.7	49.4	64.7	52	39	49.1	40	35.9	28.2
Complete Response rate (%)	11	25	11.9	12.2	29.4	12.5	0	14.5	1.8	12.8	2.6
Median time to progressive disease (months)	9.6	11.1	7.4	7.4	7			8.3	7.7	8.7	5.2
Median survival (months)	14.1	15.5	14.8	13.8	18.5	16	9	12.8	9.8	15.4	13.8
Toxicity
Grade 3 or 4; Neutropenia (%)	62	20	82	71	41.2			34.6	45.4	77	29
Neutropenic sepsis or febrile neutropenia (%)	26	10	12	1	32.4	18	3.2
Drug-related; deaths (%)	4	3	3	1		4	0			2.3	2.4