Review Article

Biologicals and Fetal Cell Therapy for Wound and Scar Management

Table 1

Regulated genes in fetal banked cells compared to young banked cells.

Enter gene IDGene symbolGene nameFold increase (expressed in log2)

3205HOXA9Homeobox A94.103
2890GRIA1Glutamate receptor, ionotropic, AMPA 14.050
3223HOXC6Homeobox C63.255
3202HOXA5Homeobox A53.243
2861GPR37G protein-coupled receptor 37 (Endothelin receptor type B-LIKE)3.221
5789PTPRSProtein tyrosine phosphatase, receptor type, D3.171
3206HOXA10Homeobox A103.084
2321FLT1FMS-related tyrosine kinase 13.060
9452ITM2AIntegral membrane protein 2A3.030
862RUNX1T1RUNT-related transcription factor 1; translocated TO, 1 (cyclin D-related)2.985
1047CLGNCalmegin2.916
744MPPED2Metallophosphoesterase domain containing 22.844
9056SLC7A7Solute carrier family 7, Member 72.806
1948EFNB2Ephrin-B22.770
23266LPHN2Latrophilin 22.714
9865KIAA0644KIAA0644 gene product2.689
23705CADM1Immunoglobulin superfamily, member 42.607
1016CDH18Cadherin 18, type 22.553
2294FOXF1Forkhead box F12.543
140462ASB9DKFZP564L0862 protein2.452
5947RBP1Retinol binding protein 1, cellular2.394
83939EIF2AEukaryotic translation initiation factor 2A, 65 KDA2.276
5918RARRES1Retinoic acid receptor responder (tazarotene induced) 12.256
3306HSPA2Heat shock 70 KDA protein 22.211
5880RAC2RAS-related C3 botulinum toxin substrate 2 (RHO family, small GTP binding protein RAC2)2.175
151230KLHL23Kelch-like 232.171
284ANGPT1Angiopoietin 12.171
2201FBN2Fibrillin 2 (congenital contractural arachnodactyly)2.164
3880KRT19Keratin 192.163
57157PHTF2Putative homeodomain transcription factor 22.147
154796AMOTAngiomotin2.121
1012CDH13Cadherin 13, H-cadherin (heart)2.086
5507PPP1R3CProtein phosphatase 1, regulatory (inhibitor) subunit 3C2.042
1908EDN3Endothelin 32.032
6319SCDStearoyl-coa desaturase (delta-9-desaturase)2.022
5307PITX1Paired-like homeodomain transcription factor 12.008
6899TBX1T-box 11.957
5099PCDH7BH-protocadherin (brain-heart)1.939
3215HOXB5Homeobox B51.880
6664SOX11Sry (sex determining region Y)-box 111.862
4004LMO1Lim domain only 1 (rhombotin 1)1.830
10924SMPDL3ASphingomyelin phosphodiesterase, acid-like 3A1.810
3233HOXD4Homeobox D41.810
3232HOXD3Homeobox D31.809
1305COL13A1Collagen, type XIII, alpha 11.772
444ASPHAspartate beta-hydroxylase1.767
5781PTPN11Protein tyrosine phosphatase, non-receptor type 11 (noonan syndrome 1)1.749
4908NTF3Neurotrophin 31.741
7046TGFBR1Transforming growth factor, beta receptor I (activin a receptor type II-like kinase, 53 KDA)1.722
5743PTGS2Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)1.708
23475QPRTQuinolinate phosphoribosyltransferase1.704
934CD24CD24 antigen1.698
10773ZBTB6Zinc finger protein 4821.685
2048EPHB2EPH receptor B21.624
23089PEG10Paternally expressed 101.617
26013L3MBTLLethal (3) malignant brain tumor L(3)MBT protein (drosophila) homolog1.614
3434IFIT1Interferon-induced protein with tetratricopeptide repeats 11.613
5156PDGFRAPlatelet-derived growth factor receptor, alpha polypeptide1.610
382ARF6ADP-ribosylation factor 61.610
2028ENPEPGlutamyl aminopeptidase (aminopeptidase A)1.607
10643IGF2BP3Insulin-like growth factor 2 MRNA binding protein 31.604
8091HMGA2High mobility group at-hook 21.580
900CCNG1Cyclin G11.579
4192MDKMidkine (neurite growth-promoting factor 2)1.577
552889LOC552889Hypothetical LOC5528891.576
540ATP7BAtpase, CU++ transporting, beta polypeptide1.565
2289FKBP5FK506 binding protein 51.543
4194MDM4MDM4, transformed 3t3 cell double minute 41.538
5764PTNPleiotrophin1.533
8935SKAP2SRC family associated phosphoprotein 21.528
273AMPHAmphiphysin1.527
2799GNSGlucosamine (N-acetyl)-6-sulfatase (sanfilippo disease IIID)1.519
5311PKD2Polycystic kidney disease 2 (autosomal dominant)1.518
10402ST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 61.501
3764KCNJ8Potassium inwardly-rectifying channel, subfamily J, member 8−1.501
6347CCL2Chemokine (C-C motif) ligand 2−1.509
2030SLC29A1Solute carrier family 29−1.517
2919CXCL1Chemokine (C-X-C MOTIF) ligand 1−1.519
1839HBEGFHeparin-binding EGF-like growth factor−1.522
3488IGFBP5Insulin-like growth factor binding protein 5−1.539
5678PSG9Pregnancy specific beta-1-glycoprotein 9−1.557
3643INSRInsulin receptor−1.569
10974C10ORF116Chromosome 10 open reading frame 116−1.580
4071TM4SF1Transmembrane 4 L six family member 1−1.580
1832DSPDesmoplakin−1.590
4487MSX1MSH homeobox homolog 1−1.613
27295PDLIM3PDZ and LIM domain 3−1.615
1294COL7A1Collagen, type VII, alpha 1−1.617
182JAG1Jagged 1 (alagille syndrome)−1.617
22891ZNF365Zinc finger protein 365−1.619
4223MEOX2Mesenchyme homeobox 2−1.660
8076MFAP5Microfibrillar associated protein 5−1.665
51363GALNAC4S-6STKIAA0598 gene product−1.676
5354PLP1Proteolipid protein 1−1.694
1410CRYABCrystallin, alpha B−1.699
4854NOTCH3Notch homolog 3−1.743
116039OSR2ODD-skipped related 2−1.753
10873ME3Malic enzyme 3, NADP(+)-dependent, mitochondrial−1.760
5865RAB3BRAB3B, member RAS oncogene family−1.764
10391CORO2BCoronin, actin binding protein, 2B−1.770
22809ATF5Activating transcription factor 5−1.782
6356CCL11Chemokine (C-C motif) ligand 11−1.783
7869SEMA3BSemaphorin 3B−1.802
8404SPARCL1SPARC-like 1 (MAST9, HEVIN)−1.813
1004CDH6Cadherin 6, type 2, K-cadherin (fetal kidney)−1.823
131578LRRC15Leucine rich repeat containing 15−1.836
3855KRT7Keratin 7−1.846
11145HRASLS3HRAS-like suppressor 3−1.853
5919RARRES2Retinoic acid receptor responder−1.862
5493PPLPeriplakin−1.882
27063ANKRD1Ankyrin repeat domain 1 (cardiac muscle)−1.891
684BST2Bone marrow stromal cell antigen 2−1.918
8190MIAMelanoma inhibitory activity−1.932
7042TGFB2Transforming growth factor, beta 2−1.950
6004RGS16Regulator of G-protein signalling 16−1.969
7020TFAP2ATranscription factor AP-2 alpha−2.008
3589IL11Interleukin 11−2.022
8549LGR5Leucine-rich repeat-containing G protein-coupled receptor 5−2.027
2277FIGFC-FOS induced growth factor−2.029
4958OMDOsteomodulin−2.047
10351ABCA8ATP-binding cassette, sub-family A (ABC1), member 8−2.051
2065ERBB3V-ERB-B2 erythroblastic leukemia viral oncogene−2.073
5649RELNReelin−2.130
6663SOX10SRY (sex determining region Y)-BOX 10−2.172
2878GPX3Glutathione peroxidase 3 (plasma)−2.183
1620DBC1Deleted in bladder cancer 1−2.208
4629MYH11Myosin, heavy polypeptide 11, smooth muscle−2.221
4046LSP1Lymphocyte-specific protein 1−2.224
5730PTGDSProstaglandin D2 synthase 21 KDA (BRAIN)−2.252
6781STC1Stanniocalcin 1−2.290
1675CFDComplement factor D (ADIPSIN)−2.298
3490IGFBP7Insulin-like growth factor binding protein 7−2.317
10439OLFM1Olfactomedin 1−2.341
23090ZNF423Zinc finger protein 423−2.372
1842ECM2Extracellular matrix protein 2−2.426
11098PRSS23Protease, serine, 23−2.431
7857SCG2SECRETOGRANIN II (CHROMOGRANIN C)−2.448
2628GATMGlycine amidinotransferase−2.463
358AQP1Aquaporin 1−2.507
8418CMAHCytidine monophosphate-N-acetylneuraminic acid hydroxylase−2.533
2006ELNElastin (supravalvular aortic stenosis, williams-beuren syndrome)−2.589
3481IGF2Insulin-like growth factor 2 (somatomedin A)−2.592
4804NGFRNerve growth factor receptor (tnfr superfamily, member 16)−2.625
2675GFRA2GDNF family receptor alpha 2−2.646
249ALPLAlkaline phosphatase, liver/bone/kidney−2.671
2596GAP43Growth associated protein 43−2.678
11075STMN2Stathmin-like 2−2.695
5803PTPRZ1Protein tyrosine phosphatase, receptor-type, Z polypeptide 1−2.695
8744TNFSF9Tumor necrosis factor superfamily, member 9−2.723
8644AKR1C3Aldo-keto reductase family 1, member C3−2.837
8839WISP2WNT1 inducible signaling pathway protein 2−2.910
124ADH1CAlcohol dehydrogenase 1A (CLASS I)−2.927
1734DIO2Deiodinase, iodothyronine, type II−2.947
1116CHI3L1Chitinase 3-like 1 (cartilage glycoprotein-39)−3.329
5320PLA2G2APhospholipase A2, group IIA (platelets, synovial fluid)−3.355
3123HLA-DRB6Major histocompatibility complex, class II, DR beta 1−3.415
3128HLA-DRB5Major histocompatibility complex, class II, DR beta 6−3.415
4915NTRK2Neurotrophic tyrosine kinase, receptor, type 2−3.552
3479IGF1Insulin-like growth factor 1 (somatomedin C)−3.682
3897L1CAML1 cell adhesion molecule−3.706
347APODApolipoprotein D−3.749
50486G0S2G0/G1switch 2−3.913
2824GPM6BGlycoprotein M6B−4.029
1299COL9A3Collagen, type IX, alpha 3−4.076
9244CRLF1Cytokine receptor-like factor 1−4.463
2662GDF10Growth differentiation factor 10−4.813
1311COMPCartilage oligomeric matrix protein−4.840