Table of Contents
ISRN Pharmaceutics
Volume 2011 (2011), Article ID 578570, 6 pages
http://dx.doi.org/10.5402/2011/578570
Research Article

Labeling of Tannic Acid with Technetium-99m for Diagnosis of Stomach Ulcer

Radioisotopes Production and Radioactive Sources Division, Labelled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

Received 6 May 2011; Accepted 8 June 2011

Academic Editors: P.-C. Kuo and M. Y. Rios

Copyright © 2011 I. T. Ibrahim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of  99mTc-tannic acid in acidic media (pH), the conditions required were 150  ๐œ‡ g tin chloride, 30 min reaction time, and 200  ๐œ‡ g of the substrate. 99mTc-tannic was stable for 6 h. Oral biodistribution of 99mTc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of 99mTc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.