International Scholarly Research Notices / 2011 / Article / Fig 3

Research Article

Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs

Figure 3

Mean systemic exposure parameters (±SD) for plasma lidocaine (a) and bupivacaine (b) after high (4 mg/kg) subcutaneous dose of lidocaine/epinephrine and EXPAREL ( 𝑁 = 3 /group unless noted). Series 1: A U C 0 2 4 h r  (ng/mL·hr). Series 2: 𝐶 m a x  (ng/mL). Notes: SD was not calculated for mean plasma bupivacaine concentrations at 5 minutes ( 𝑁 = 2 ) because one animal received 55% of the intended dose of EXPAREL; therefore, data from this animal were not used in calculation of means; individual values for A U C 0 2 4 h r = 2,980 and 5,770 ng/mL·hr and for 𝐶 m a x = 3,690 and 7,770 ng/mL.

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