International Scholarly Research Notices / 2011 / Article / Tab 1

Research Article

Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs

Table 1

Pharmacokinetic parameters for lidocaine after administration of EXPAREL and lidocaine/epinephrine solution (4 : 4 dose ratio).

Time interval (min)aParameters for plasma lidocaine
(% change from lidocaine control)
A U C 0 2 4 h r  (hr·ng/mL) 𝐶 m a x  (ng/mL)

0 3 , 4 9 0 ± 1 , 1 6 0 1 , 0 7 0 ± 8 2 . 9
5 5 , 1 7 0 ± 1 , 8 6 0 (+48%) 1 8 , 6 0 0 ± 5 , 4 7 2 (+1,640%)
10 1 , 7 2 0 ± 2 0 2 (−51%) 1 , 2 0 0 ± 1 0 4 (+12%)
20 2 , 2 9 0 ± 2 6 9 (−34%) 7 2 3 ± 2 0 6 (−32%)
40 1 , 9 8 0 ± 8 2 7 (−76%) 7 7 4 ± 1 2 7 (−28%)

a 𝑁 = 3 per group. Please refer to Section 2.2 for experimental details.

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