Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs

Table 1

Pharmacokinetic parameters for lidocaine after administration of EXPAREL and lidocaine/epinephrine solution (4 : 4 dose ratio).

Time interval (min)^a	Parameters for plasma lidocaine
	(% change from lidocaine control)
	AUC0−24hr (hr·ng/mL)	𝐶max (ng/mL)
0	3,490±1,160	1,070±82.9
5	5,170±1,860 (+48%)	18,600±5,472 (+1,640%)
10	1,720±202 (−51%)	1,200±104 (+12%)
20	2,290±269 (−34%)	723±206 (−32%)
40	1,980±827 (−76%)	774±127 (−28%)

^a𝑁=3 per group. Please refer to Section 2.2 for experimental details.