Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs

Table 2

Pharmacokinetic parameters for bupivacaine after administration of EXPAREL and lidocaine/epinephrine solution (4 : 4 dose ratio).

Time interval (min)^a	Parameters for plasma bupivacaine
	(% change from bupivacaine control)
	AUC0−24hr (hr·ng/mL)	𝐶max  (ng/mL)
0	2,240±721	519±230
5^b	4,370 (+95%); (2,980–5,770)	5,730 (+1,000%); (3,690–7,770)
10	3,370±1,980 (+50%)	865±488 (+67%)
20	2,100±445 (−6%)	412±113 (−21%)
40	2,150±410 (−4%)	422±119 (−19%)

^a𝑁=3 per group (unless noted); ^b𝑁=2; one animal received 55% of the intended dose of EXPAREL. Data from this animal were not used in calculation of means.