International Scholarly Research Notices / 2011 / Article / Tab 2

Research Article

Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs

Table 2

Pharmacokinetic parameters for bupivacaine after administration of EXPAREL and lidocaine/epinephrine solution (4 : 4 dose ratio).

Time interval (min)aParameters for plasma bupivacaine
(% change from bupivacaine control)
A U C 0 2 4 h r  (hr·ng/mL) 𝐶 m a x  (ng/mL)

0 2 , 2 4 0 ± 7 2 1 5 1 9 ± 2 3 0
5b4,370 (+95%)
(2,980–5,770)
5,730 (+1,000%)
(3,690–7,770)
10 3 , 3 7 0 ± 1 , 9 8 0 (+50%) 8 6 5 ± 4 8 8 (+67%)
20 2 , 1 0 0 ± 4 4 5 (−6%) 4 1 2 ± 1 1 3 (−21%)
40 2 , 1 5 0 ± 4 1 0 (−4%) 4 2 2 ± 1 1 9 (−19%)

a 𝑁 = 3 per group (unless noted); b 𝑁 = 2 ; one animal received 55% of the intended dose of EXPAREL. Data from this animal were not used in calculation of means.

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