Table of Contents
ISRN Otolaryngology
Volume 2011, Article ID 582374, 2 pages
Case Report

Collision Tumor of the Thyroid Gland: Primary Squamous Cell and Papillary Thyroid Carcinoma

1Department of Otolaryngology, Head and Neck Surgery, Kaplan Medical Center, P.O.B. 1, Rehovot 76100, Israel
2Hebrew University Hadassah Medical School, Ein Kerem, P.O.B. 1200, Jerusalem 91120, Israel
3Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, P.O.B. 39040, Tel-Aviv 69978, Israel
4Department of Pathology, Kaplan Medical Center, P.O.B. 1, Rehovot 76100, Israel

Received 14 March 2011; Accepted 12 April 2011

Academic Editors: M. B. Paiva and V. Sciarretta

Copyright © 2011 Meir Warman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Collision tumor of the thyroid gland is defined when independent and histologically distinct tumors coexist within the gland. The presence of both papillary and squamous cell carcinoma in the thyroid gland is unusual. Suggested etiologies include embryonic remanents of squamous epithelium, chronic inflammation, or thyroid malignancies promoting squamous metaplasia. Case Presentation. An elderly patient presented with a rapid enlargement of a long-standing right thyroid nodule. The tumor was locally invasive and unresectable. Pathology revealed the diagnosis of papillary and squamous cell carcinoma of the thyroid gland. Possible primary sites for squamous cell carcinoma in upper aerodigestive tract were excluded. The patient outcome was fatal although palliative chemoradiotherapy. Discussion. Collision tumor of papillary and squamous cell carcinoma of the thyroid gland is a rare entity that may imply bad prognosis, as to the presence of the squamous portion. The best treatment includes resection of the tumor; unfortunately it is not possible in most cases.