Table of Contents
ISRN Veterinary Science
Volume 2011 (2011), Article ID 584342, 5 pages
http://dx.doi.org/10.5402/2011/584342
Research Article

Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats

1Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Junagadh Agricultural University, Junagadh 362 001, Gujarat State, India
2Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar 385506, Dantiwada, India

Received 5 November 2011; Accepted 20 December 2011

Academic Editor: I. Nsahlai

Copyright © 2011 Harshad B. Patel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was carried out to investigate disposition kinetics of moxifloxacin following single-dose intravenous (i.v.), intramuscular (i.m.), and subcutaneous (s.c.) administration at a dose rate of 5 mg/kg of body weight (b.wt.) in goats. Plasma samples collected after treatments were analyzed for drug concentration using high-performance liquid chromatography (HPLC). After i.v. administration, distribution of the drug was rapid and wide as reflected by high steady-state volume of distribution. Drug elimination was relatively faster with a total body clearance of 0 . 5 9 ± 0 . 0 3  L/h/kg. Following i.m. injection, the drug has shown the rapid and near-to-complete absorption with bioavailability of 9 8 . 2 0 ± 3 . 9 6 per cent. The maximum plasma drug concentration ( 𝐶 m a x ) of 1 . 2 1 ± 0 . 0 4 μg/mL was attained at 1 h ( 𝑇 m a x ). The drug was widely distributed as reflected by high apparent volume of distribution. The elimination half-life ( 𝑡 1 / 2 𝛽 ) of the drug was 6 . 2 6 ± 0 . 0 8  h. Following s.c. administration, the drug was rapidly absorbed ( 𝐶 m a x : 1 . 1 6 ± 0 . 0 2 μg/mL; 𝑡 m a x : 1 h) and slowly eliminated from the body. The elimination half-life and total body clearance ( C l B ) were 5 . 6 1 ± 0 . 1 0  h and 0 . 6 0 ± 0 . 0 3  L/h/kg, respectively. The bioavailability of moxifloxacin following s.c. administration was 9 0 . 4 4 ± 3 . 9 6 per cent.