International Scholarly Research Notices

Research Article

Disposition Kinetic of Moxifloxacin following Intravenous, Intramuscular, and Subcutaneous Administration in Goats

Table 1

Pharmacokinetic parameters (Mean ± S.E.) of moxifloxacin after intravenous, intramuscular, and subcutaneous administration at a dosage of 5 mg/kg of b.wt. in male goat ( 𝑛 = 6 ).
Pharmacokinetic parametersUnitsIntravenousIntramuscularSubcutaneous
𝑡 1 / 2 𝛼 h 0 . 7 4 ± 0 . 0 4 ——
𝑡 1 / 2 k a h— 0 . 9 6 ± 0 . 1 9 0 . 8 2 ± 0 . 1 1
𝑡 1 / 2 𝛽 h 4 . 1 2 ± 0 . 3 0 6 . 2 6 ± 0 . 0 9 5 . 6 1 ± 0 . 1 0
A U C 0 - ∞ (μg·h/mL) 8 . 6 5 ± 0 . 4 2 8 . 4 8 ± 0 . 1 8 7 . 7 5 ± 0 . 2 0
AUMC(μg·h2/mL) 2 4 . 9 2 ± 2 . 1 3 6 7 . 7 4 ± 1 . 9 5 5 4 . 4 2 ± 1 . 7 0
V d a r e a (L/kg) 3 . 4 9 ± 0 . 3 2 5 . 2 5 ± 0 . 3 0 4 . 7 4 ± 0 . 2 6
V d s s (L/kg) 5 . 0 0 ± 0 . 4 6 3 . 3 9 ± 0 . 7 8 3 . 7 3 ± 1 . 2 8
C l B (L/kg/h) 0 . 5 9 ± 0 . 0 3 0 . 5 8 ± 0 . 0 3 0 . 6 0 ± 0 . 0 3
MRT(h) 7 . 0 2 ± 0 . 4 8 8 . 0 0 ± 0 . 2 3 7 . 0 3 ± 0 . 1 3
𝐶 m a x (μg/mL)— 1 . 2 1 ± 0 . 0 4 1 . 1 6 ± 0 . 0 2
𝑇 m a x (h)—1.001.00
𝐹 (%)— 9 8 . 2 0 ± 3 . 9 6 9 0 . 4 4 ± 3 . 9 6
𝑡 1 / 2 𝛼 : half-life of distribution phases; 𝑡 1 / 2 k a : absorption half-life; 𝑡 1 / 2 𝛽 : elimination half-life; A U C ( 0 - ∞ ) : area under the curve from zero to infinity; AUMC: area under first of moment curve; V d a r e a : apparent volume of distribution; V d s s : volume of distribution at steady state; C l B : total body clearance; MRT: mean residence time; 𝐶 m a x : maximum drug concentration; 𝑇 m a x : time to peak plasma drug concentration; 𝐹 : bioavailability.