Table of Contents
ISRN Neurology
Volume 2011 (2011), Article ID 590249, 7 pages
http://dx.doi.org/10.5402/2011/590249
Review Article

Ion Channels in Glioblastoma

Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

Received 4 August 2011; Accepted 19 September 2011

Academic Editors: A. Gambardella, J. A. Rey, and R. Yamanaka

Copyright © 2011 Remco J. Molenaar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated in glioblastoma proliferation, migration, and invasion. This paper summarizes studies on potassium, sodium, chloride, and calcium channels of glioblastoma. It provides an up-to-date overview of the literature that could ultimately lead to new therapeutic targets.