Table of Contents
ISRN Gastroenterology
Volume 2011, Article ID 604071, 6 pages
http://dx.doi.org/10.5402/2011/604071
Research Article

Quercetin Treatment Ameliorates Systemic Oxidative Stress in Cirrhotic Rats

1Laboratory of Experimental Hepatology and Physiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90050170 Porto Alegre, RS, Brazil
2Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, 92120-015 Canoas, RS, Brazil
3Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), 90050-170 Porto Alegre, RS, Brazil
4Laboratório de Estresse Oxidativo e Antioxidantes (ULBRA), Avenida Farroupilha 8001, Bairro São José, 92425-900 Canoas, RS, Brazil

Received 18 April 2011; Accepted 16 June 2011

Academic Editor: F. Izzo

Copyright © 2011 Emanuelle Kerber Vieira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Our aim was to investigate whether the antioxidant quercetin protects against liver injury and ameliorates the systemic oxidative stress in rats with common bile duct ligation. Secondary biliary cirrhosis was induced through 28 days of bile duct obstruction. Animals received quercetin (Q) after 14 days of obstruction. Groups of control (CO) and cirrhotic (CBDL) animals received a daily 50 mg/kg body weight i.p. injection of quercetin (CO + Q; CBDL + Q) or vehicle (CO; CBDL). Quercetin corrected the reduction in superoxide dismutase (SOD), catalase CAT, and glutathione peroxidase GPx activities and prevented the increase of thiobarbituric acid reactive substances (TBARS), aminotransferases, and alkaline phosphatase in cirrhotic animals. Quercetin administration also corrected the reduced total nitrate concentration in the liver and prevented liver fibrosis and necrosis. These effects suggest that quercetin might be a useful agent to preserve liver function and prevent systemic oxidative stress.