Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011, Article ID 617082, 3 pages
http://dx.doi.org/10.5402/2011/617082
Research Article

Epithelial Ovarian Cancer and the Occurrence of Skin Cancer in The Netherlands: Histological Type Connotations

1Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
2Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

Received 1 March 2011; Accepted 20 March 2011

Academic Editors: A. Jazaeri and E. Petru

Copyright © 2011 Catharina C. van Niekerk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Patients with epithelial ovarian cancer have a high risk of (non-)melanoma skin cancer. The association between histological variants of primary ovarian cancer and skin cancer is poorly documented. Objectives. To further evaluate the risk of skin cancer based on the histology of the epithelial ovarian cancer. Methods. A cross-sectional study within a large population-based dataset. Results. Skin cancer was found in 2 . 7 % ( 9 5 % CI: 2.3–3.1) of the 5366 individuals forming our dataset. The odds ratio (OR) for endometrioid cancer in the ovary to skin cancer in the under 50 age group was 8.9 ( 9 5 % CI: 3.2–25.0). The OR decreased in older patients to 1.2. Conclusions. Patients with epithelial ovarian malignancies show an increased risk of skin cancer. A significantly increased risk ( 4 . 3 % ) for endometrioid ovarian cancer was found in the group aged under 50.