Table of Contents
ISRN Neurology
Volume 2011, Article ID 618624, 6 pages
Research Article

Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke

1Department of Pharmacy Practice, KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore, Tamilnadu 48, India
2Department of Neurology, Kovai Medical Center and Hospital, Coimbatore, Tamilnadu 44, India
3Department of Pharmacy, Madurai Medical College, Madurai, Tamilnadu 20, India

Received 4 August 2011; Accepted 20 September 2011

Academic Editor: M. Xue

Copyright © 2011 Palanisamy Sivanandy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to evaluate the efficacy and safety of thrombolytic therapy. Our study enrolled 23 patients out of which 2 patients died due to ICH; we also found that only 39% of patients reached hospital within stroke window, and for those treated, mean NIHSS during admission was 14.0, but drastic improvement was shown after 24 hours of treatment, that is, 9.89 ( 𝑃 < 0 . 0 0 0 1 ), and at discharge, it was 5.1 ( 𝑃 < 0 . 0 0 0 1 ) which showed a clear impact of the treatment, and around 60% of patients were discharged within an mRS score of 1 and 2. Hence, it was found that thrombolytic therapy was beneficial, efficacious, and safe if used within 3 to 4.5 hours.