Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 627623, 7 pages
Research Article

Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology

1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004, India
2Department of Pharmaceutics, Royal College of Pharmacy & Health Sciences, Andhapasara Road, Berhampur, Orissa 760002, India

Received 31 March 2011; Accepted 1 May 2011

Academic Editors: A. Al-Achi and C. Saturnino

Copyright © 2011 Sanjay Dey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 3 2 full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio ( 𝑋 1 ) and stirring speed ( 𝑋 2 ), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm. The drug release was also sustained for more than 12 hours. The study helped in finding the optimum formulation with excellent sustained drug release.