Table of Contents
ISRN Cardiology
Volume 2011, Article ID 638764, 5 pages
http://dx.doi.org/10.5402/2011/638764
Research Article

Increased B-Type Natriuretic Peptide Concentration Is Associated with Reduced Coronary Vasoreactivity in Patients with Dilated Cardiomyopathy but Not in Healthy Young Subjects

1Turku PET Centre, University of Turku, P.O. Box 52, 20521 Turku, Finland
2Department of Medicine, University of Turku, 20520 Turku, Finland
3Department of Medicine, Satakunta Central Hospital, 28500 Pori, Finland
4Department of Cardiology, Leiden University, 2333 ZA Leiden, The Netherlands

Received 2 March 2011; Accepted 23 March 2011

Academic Editor: M. Takahashi

Copyright Β© 2011 Jan Sundell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims. Natriuretic peptides are associated with the cardiovascular disease risk under a range of different circumstances. However, less is known about whether this association is found also in young healthy subjects. Methods. 9 patients with dilated cardiomyopathy and 26 healthy young subjects were studied. The myocardial blood flow measurements were performed basally and during adenosine infusion using PET. Results. S-proBNP concentrations were significantly higher ( 2 1 5 3 Β± 1 9 6 4 versus 2 8 Β± 1 7  ng/L, 𝑃 = . 0 0 0 0 0 2 ) and adenosine-stimulated flow lower ( 1 . 6 Β± 0 . 8 versus 3 . 6 Β± 1 . 1  mL β‹… g−1 β‹… min−1, 𝑃 = . 0 0 0 0 1 ) in patients with dilated cardiomyopathy when compared to healthy subjects. S-proBNP concentration was inversely associated with adenosine stimulated flow in patients with dilated cardiomyopathy ( π‘Ÿ = βˆ’ 0 . 7 5 , 𝑃 = . 0 1 9 ) but not in healthy subjects ( π‘Ÿ = βˆ’ 0 . 0 6 , 𝑃 = . 8 4 ). Conclusions. Natriuretic peptides are inversely associated with coronary vasoreactivity in patients with dilated cardiomyopathy but not in healthy young subjects. Since reduced coronary vasoreactivity seems to be one of the earliest abnormalities in the development of coronary artery disease, this might indicate that natriuretic peptides are not predictor of cardiovascular disease risk in healthy young subjects.