Table of Contents
ISRN Oncology
Volume 2011, Article ID 645450, 10 pages
http://dx.doi.org/10.5402/2011/645450
Clinical Study

Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis

1Third Department of Surgery, SB Okmeydanı Training and Research Hospital, Istanbul, Turkey
2Fifth Department of Surgery, SB Okmeydanı Training and Research Hospital, Istanbul, Turkey
3Department of Surgery, Bayındır Levent Hospital, Istanbul, Turkey

Received 21 June 2011; Accepted 17 July 2011

Academic Editors: M. Emoto, A. M. Garcia-Lora, and M. R. Pfeffer

Copyright © 2011 Nüvit Duraker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We evaluated the prognostic significance of lymph node ratio (LNR), number of metastatic lymph nodes divided by number of removed nodes in 924 breast carcinoma patients with 1–3 metastatic axillary lymph node(s). The most significant LNR threshold value separating patients in low- and high-risk groups with significant survival difference was 0.20 for disease-free survival ( 𝑃 < 0 . 0 0 1 ), 0.30 for locoregional recurrence-free survival ( 𝑃 < 0 . 0 0 1 ), and 0.15 for distant metastasis-free survival ( 𝑃 < 0 . 0 0 1 ), and the patients with lower LNR had better survival. All three LNR threshold values had independent prognostic significance in Cox analysis ( 𝑃 < 0 . 0 0 1 for all three of them). In conclusion, LNR is a useful tool in separating breast carcinoma patients with 1–3 metastatic lymph node(s) into low- and high-risk prognostic groups.