Table of Contents
ISRN Ophthalmology
Volume 2011, Article ID 648450, 6 pages
Research Article

Diffusion Tensor Imaging for In Vivo Detection of Degenerated Optic Radiation

1Department of Opthtalmology, University Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
2Department of Neuroradiology, University Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany

Received 18 October 2011; Accepted 20 November 2011

Academic Editor: Á. Szél

Copyright © 2011 Georg Michelson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Glaucomatous optic nerve atrophy may continue to the linked optic radiation by transneuronal degeneration, as described in animal models of glaucoma. In vivo visualization of the visual pathway represents a new challenge in the field of ophthalmology. We present a new approach for illustration of the optic radiation by diffusion tensor imaging (DTI) based on magnetic resonance imaging (MRI). The DTI was established by use of a 3T high-field scanner. The case of a patient with primary open-angle glaucoma is opposed to this one of a healthy subject to demonstrate the visible rarefication of the optic radiation. The goal was to introduce the technique of the DTI also in ophthalmology and to demonstrate that it may be useful to judge glaucoma-related differences.