Table of Contents
ISRN Pediatrics
Volume 2011 (2011), Article ID 651749, 5 pages
http://dx.doi.org/10.5402/2011/651749
Research Article

Hemolytic-Uremic Syndrome in Uberlândia, MG, Brazil

1Department of Pediatrics, Universidade Federal de Uberlândia, MG, Brazil
2Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, SP, Brazil

Received 28 August 2011; Accepted 20 October 2011

Academic Editor: C. D. Berkowitz

Copyright © 2011 V. Bonetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To analyze the epidemiological, clinical, and laboratory characteristics of hemolytic-uremic syndrome (HUS) in Uberlandia, MG, Brazil. Methods. A historical cohort study was performed encompassing a ten-year period from January 1994 to January 2004 in the Department of Pediatric Nephrology at a full-service hospital; demographic factors, triggering factors, time of hospitalization, supportive therapy, and disease progression were analyzed. Results. Twenty-seven children aged 5 to 99 months (median age of 14 months) were studied; 70.4% were male. Of the 27 patients, 77.8% were from urban areas and 18.5% were from rural areas. Eight of the patients (29.6%) were reported to drink raw milk, and clinical diarrhea was reported in 81.5% of cases. The most common signs and symptoms were fever and vomiting (85.1%), anuria (63.0%), seizure (33.0%), cardiac involvement (11.0%), and acute pulmonary edema (7.4%). Dialysis was performed on 20 patients (74%). The mean hospital stay was 24 days (range: 13 to 36 days). While monitoring the patients, 2 died (7.4%), 3 developed chronic kidney disease (11.0%), and 21 (77.8%) developed hypertension. Conclusion. Our results emphasize the possibility of diagnosing HUS as a cause of renal failure in childhood in both typical (postdiarrheal) and atypical forms and suggest that an investigation of the etiological agent should be made whenever possible.